Seroatlas · Human Serome Atlas

H3C15

Histone H3.2

Also known as: H3, H3.2, H3/m, H3/n, H3/o, H32_HUMAN, H3C13, H3C14, H3F2, H3FM, HIST2H3A, HIST2H3C, HIST2H3D, MGC9629

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q71DI3
Gene: H3C15
Ensembl: ENSG00000203852
Chromosome: 1
Canonical length: 136 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Acrosome,Principal piece

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>Q71DI3|H3C15
     1  MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE
    61  LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEASEAY LVGLFEDTNL CAIHAKRVTI
   121  MPKDIQLARR IRGERA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H3C15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 3.3 nTPM
esophagus: 1.2 nTPM
ovary: 1.2 nTPM
spleen: 1.1 nTPM
cerebellum: 1 nTPM
lung: 0.9 nTPM

Single-cell type

tuft cells: 12 nCPM
erythrocyte progenitors: 6 nCPM
monocyte progenitors: 3.5 nCPM
cardiomyocytes: 2.7 nCPM
megakaryocyte progenitors: 2.5 nCPM
parietal cells: 1.8 nCPM

Immune cell

neutrophil: 8.9 nTPM
naive B-cell: 4.6 nTPM
plasmacytoid DC: 2.1 nTPM
MAIT T-cell: 1.8 nTPM
intermediate monocyte: 1.5 nTPM
memory CD8 T-cell: 1.3 nTPM

Brain region

cerebellum: 32 nTPM
hypothalamus: 28 nTPM
spinal cord: 14 nTPM
choroid plexus: 13 nTPM
white matter: 12 nTPM
basal ganglia: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H3C15.

Disease | ImmuneIEDB

Conditions an epitope on H3C15 was assayed in.

systemic lupus erythematosus B and T cell
rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H3C15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H3C15 as an antibody target. Whether an autoantibody or antibody against H3C15 could matter depends on whether native H3C15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H3C15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H3C15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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