Seroatlas · Human Serome Atlas

H2BC12L

Histone H2B type F-S

Also known as: H2BFS, H2BFS_HUMAN, H2BS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P57053
Gene
H2BC12L
Ensembl
ENSG00000234289
Chromosome
21
Canonical length
126 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and innate immune response in mucosa. Located in cytosol; extracellular space; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>P57053|H2BC12L
     1  MPEPAKSAPA PKKGSKKAVT KAQKKDGRKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
    61  GIMNSFVNDI FERIAGEASR LPHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
   121  KYTSAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC12L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
1.9 nTPM

Expression across tissuesHPA

Tissue

  • gallbladder: 1.9 nTPM
  • lymph node: 1.4 nTPM
  • epididymis: 0.4 nTPM
  • spleen: 0.2 nTPM
  • stomach: 0.2 nTPM
  • adipose tissue: 0.1 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • eosinophil: 0.8 nTPM
  • basophil: 0.6 nTPM
  • naive B-cell: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • memory B-cell: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM

Brain region

  • pons: 0.6 nTPM
  • cerebral cortex: 0.5 nTPM
  • choroid plexus: 0.5 nTPM
  • medulla oblongata: 0.5 nTPM
  • white matter: 0.5 nTPM
  • amygdala: 0.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BC12L.

Disease | ImmuneIEDB

Conditions an epitope on H2BC12L was assayed in.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC12L as an antibody target. Whether an autoantibody or antibody against H2BC12L could matter depends on whether native H2BC12L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC12L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and innate immune response in mucosa.

Canonical record: https://seroatlas.com/gene/H2BC12L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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