Seroatlas · Human Serome Atlas

H3Y1

Histone H3.Y

Also known as: H3.Y, H3.Y.1, H3Y1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DPK2
Gene
H3Y1
Ensembl
ENSG00000269466
Chromosome
5
Canonical length
136 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Acrosome,Principal piece

OverviewNCBI Gene

Enables nucleosomal DNA binding activity. Located in nucleoplasm. Part of nucleosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>P0DPK2|H3Y1
     1  MARTKQTARK ATAWQAPRKP LATKAAGKRA PPTGGIKKPH RYKPGTLALR EIRKYQKSTQ
    61  LLLRKLPFQR LVREIAQAIS PDLRFQSAAI GALQEASEAY LVQLFEDTNL CAIHARRVTI
   121  MPRDMQLARR LRREGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H3Y1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.2 nTPM
  • blood vessel: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • epididymis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • early spermatids: 4.9 nCPM
  • late spermatids: 3.4 nCPM
  • epididymal principal cells: 2.1 nCPM
  • differentiating spermatogonia: 0.7 nCPM
  • undifferentiated spermatogonia: 0.7 nCPM
  • early primary spermatocytes: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H3Y1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H3Y1 as an antibody target. Whether an autoantibody or antibody against H3Y1 could matter depends on whether native H3Y1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H3Y1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H3Y1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H3Y1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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