Seroatlas · Human Serome Atlas

H3C1

Histone H3.1

Also known as: H3.1, H3.f, H3/A, H3/b, H3/c, H3/d, H3/f, H3/h, H3/i, H3/j, H3/k, H3/l, H31_HUMAN, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3F1K, H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P68431
Gene
H3C1
Ensembl
ENSG00000275714
Chromosome
6
Canonical length
136 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Acrosome,Principal piece

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>P68431|H3C1
     1  MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE
    61  LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEACEAY LVGLFEDTNL CAIHAKRVTI
   121  MPKDIQLARR IRGERA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H3C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
1.2 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 1.2 nTPM
  • thymus: 1 nTPM
  • lymph node: 0.9 nTPM
  • spleen: 0.4 nTPM
  • testis: 0.3 nTPM
  • placenta: 0.2 nTPM

Single-cell type

  • colonocytes: 167 nCPM
  • enterocytes: 128 nCPM
  • goblet cells: 82 nCPM
  • platelets: 68 nCPM
  • syncytiotrophoblasts: 62 nCPM
  • erythrocyte progenitors: 59 nCPM

Immune cell

  • memory CD8 T-cell: 0.9 nTPM
  • memory CD4 T-cell: 0.7 nTPM
  • myeloid DC: 0.7 nTPM
  • T-reg: 0.7 nTPM
  • naive B-cell: 0.5 nTPM
  • gdT-cell: 0.4 nTPM

Brain region

  • midbrain: 4.7 nTPM
  • pons: 3.2 nTPM
  • choroid plexus: 3 nTPM
  • white matter: 3 nTPM
  • thalamus: 2.1 nTPM
  • medulla oblongata: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H3C1.

Disease | AllUniProt

Conditions H3C1 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 46 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on H3C1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H3C1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H3C1 as an antibody target. Whether an autoantibody or antibody against H3C1 could matter depends on whether native H3C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H3C1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H3C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H3C1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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