Seroatlas · Human Serome Atlas

H2BK1

Histone H2B type 2-K1

Also known as: H2BE1, H2BK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A2R8Y619
Gene
H2BK1
Ensembl
ENSG00000285480
Chromosome
7
Canonical length
122 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>A0A2R8Y619|H2BK1
     1  MSAEYGQRQQ PGGRGGRSSG NKKSKKRCRR KESYSMYIYK VLKQVHPDIG ISAKAMSIMN
    61  SFVNDVFEQL ACEAARLAQY SGRTTLTSRE VQTAVRLLLP GELAKHAVSE GTKAVTKYTS
   121  SK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
3.1 nTPM

Expression across tissuesHPA

Tissue

  • skin: 3.1 nTPM
  • endometrium: 0.9 nTPM
  • lymph node: 0.9 nTPM
  • adipose tissue: 0.7 nTPM
  • skeletal muscle: 0.7 nTPM
  • spleen: 0.7 nTPM

Single-cell type

  • oocytes: 9.2 nCPM
  • oligodendrocytes: 1.1 nCPM
  • granulosa cells: 0.8 nCPM
  • b-cells: 0.5 nCPM
  • microglia: 0.5 nCPM
  • astrocytes: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 2.1 nTPM
  • pons: 1.6 nTPM
  • thalamus: 1.6 nTPM
  • white matter: 1.6 nTPM
  • cerebellum: 1.5 nTPM
  • medulla oblongata: 1.5 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BK1 as an antibody target. Whether an autoantibody or antibody against H2BK1 could matter depends on whether native H2BK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2BK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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