Seroatlas · Human Serome Atlas

NFYC

Nuclear transcription factor Y subunit gamma

Also known as: CBF-C, NF-YC, NFYC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13952
Gene: NFYC
Ensembl: ENSG00000066136
Chromosome: 1
Canonical length: 458 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q13952|NFYC
     1  MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM
    61  ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR
   121  DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII
   181  AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP
   241  VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQGQRN ASQGKPRRCL KETLQITQTE
   301  VQQGQQQFSQ FTDGQRNSVQ QARVSELTGE AEPREVKATG NSTPCTSSLP TTHPPSHRAG
   361  ASCVCCSQPQ QSSTSPPPSD ALQWVVVEVS GTPNQLETHR ELHAPLPGMT SLSPLHPSQQ
   421  LYQIQQVTMP AGQDLAQPMF IQSANQPSDG QAPQVTGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFYC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 68 nTPM
tongue: 59 nTPM
heart muscle: 57 nTPM
parathyroid gland: 47 nTPM
salivary gland: 44 nTPM
cerebellum: 42 nTPM

Single-cell type

neutrophils: 365 nCPM
cardiomyocytes: 281 nCPM
choroid plexus epithelial cells: 238 nCPM
oocytes: 230 nCPM
myonuclei: 200 nCPM
distal convoluted tubule cells: 185 nCPM

Immune cell

neutrophil: 102 nTPM
non-classical monocyte: 80 nTPM
intermediate monocyte: 68 nTPM
eosinophil: 64 nTPM
classical monocyte: 61 nTPM
myeloid DC: 59 nTPM

Brain region

cerebellum: 62 nTPM
choroid plexus: 61 nTPM
cerebral cortex: 56 nTPM
white matter: 53 nTPM
thalamus: 49 nTPM
basal ganglia: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.11
gnomAD missense Z: 2.52
DepMap mean gene effect: -0.8
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFYC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFYC as an antibody target. Whether an autoantibody or antibody against NFYC could matter depends on whether native NFYC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFYC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFYC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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