Seroatlas · Human Serome Atlas

H2AC12

Histone H2A type 1-H

Also known as: dJ86C11.1, H2A/S, H2A1H_HUMAN, H2AFALii, HIST1H2AH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KK5
Gene: H2AC12
Ensembl: ENSG00000274997
Chromosome: 6
Canonical length: 128 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q96KK5|H2AC12
     1  MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT
    61  AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK
   121  TESHHKAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 8.3 nTPM
small intestine: 1.9 nTPM
testis: 1.5 nTPM
thymus: 1.4 nTPM
lymph node: 1.1 nTPM
colon: 0.7 nTPM

Single-cell type

erythrocyte progenitors: 215 nCPM
megakaryocyte progenitors: 85 nCPM
monocyte progenitors: 81 nCPM
tuft cells: 46 nCPM
plasma cells: 34 nCPM
neutrophil progenitors: 27 nCPM

Immune cell

naive B-cell: 12 nTPM
NK-cell: 5.1 nTPM
memory CD4 T-cell: 4.1 nTPM
memory CD8 T-cell: 3.8 nTPM
memory B-cell: 3.3 nTPM
intermediate monocyte: 2.3 nTPM

Brain region

white matter: 8.2 nTPM
thalamus: 6.3 nTPM
pons: 5.9 nTPM
spinal cord: 5.9 nTPM
medulla oblongata: 5.5 nTPM
midbrain: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
DepMap mean gene effect: -0.73
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

heterochromatin formation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AC12 as an antibody target. Whether an autoantibody or antibody against H2AC12 could matter depends on whether native H2AC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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