H2BC18
Histone H2B type 2-F
Also known as: H2B2F_HUMAN, HIST2H2BF
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5QNW6
- Gene
- H2BC18
- Ensembl
- ENSG00000203814
- Chromosome
- 1
- Canonical length
- 126 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and is found in a histone cluster on chromosome 1. [provided by RefSeq, Aug 2015]
Canonical amino-acid sequenceUniProt
126 residues, UniProt reviewed canonical sequence.
>Q5QNW6|H2BC18
1 MPDPAKSAPA PKKGSKKAVT KVQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
61 GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
121 KYTSSKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against H2BC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 36 nTPM
Expression across tissuesHPA
Tissue
- cervix: 36 nTPM
- vagina: 35 nTPM
- ovary: 33 nTPM
- lung: 30 nTPM
- prostate: 26 nTPM
- skin: 18 nTPM
Single-cell type
- microglia: 89 nCPM
- prostatic club cells: 82 nCPM
- basal prostatic cells: 77 nCPM
- prostatic hillock cells: 64 nCPM
- tuft cells: 58 nCPM
- epididymal principal cells: 54 nCPM
Immune cell
- neutrophil: 45 nTPM
- naive B-cell: 5.5 nTPM
- memory CD4 T-cell: 2.7 nTPM
- classical monocyte: 2.5 nTPM
- gdT-cell: 2.4 nTPM
- memory B-cell: 2.1 nTPM
Brain region
- cerebellum: 130 nTPM
- choroid plexus: 128 nTPM
- midbrain: 103 nTPM
- hypothalamus: 103 nTPM
- white matter: 97 nTPM
- medulla oblongata: 94 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about H2BC18.
Disease | ImmuneIEDB
Conditions an epitope on H2BC18 was assayed in.
- rheumatoid arthritis B cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.27
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads H2BC18 as an antibody target. Whether an autoantibody or antibody against H2BC18 could matter depends on whether native H2BC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
H2BC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label H2BC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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