Seroatlas · Human Serome Atlas

H2AJ

Histone H2A.J

Also known as: FLJ10903, H2AFJ, H2AJ_HUMAN, MGC921

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTM1
Gene: H2AJ
Ensembl: ENSG00000246705
Chromosome: 12
Canonical length: 129 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>Q9BTM1|H2AJ
     1  MSGRGKQGGK VRAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT
    61  AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK
   121  TESQKTKSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 541 nTPM

Expression across tissuesHPA

Tissue

testis: 541 nTPM
prostate: 278 nTPM
blood vessel: 274 nTPM
adipose tissue: 236 nTPM
breast: 223 nTPM
skin: 201 nTPM

Single-cell type

late spermatids: 6,092 nCPM
late primary spermatocytes: 4,295 nCPM
esophageal apical cells: 3,320 nCPM
early spermatids: 2,735 nCPM
platelets: 1,247 nCPM
prostatic glandular cells: 664 nCPM

Immune cell

classical monocyte: 133 nTPM
myeloid DC: 122 nTPM
basophil: 87 nTPM
T-reg: 81 nTPM
intermediate monocyte: 79 nTPM
total PBMC: 75 nTPM

Brain region

white matter: 38 nTPM
choroid plexus: 36 nTPM
medulla oblongata: 36 nTPM
pons: 29 nTPM
thalamus: 27 nTPM
basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0.25
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

heterochromatin formation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AJ as an antibody target. Whether an autoantibody or antibody against H2AJ could matter depends on whether native H2AJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AJ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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