Seroatlas · Human Serome Atlas

H2AZ1

Histone H2A.Z

Also known as: H2A.Z, H2AFZ, H2AZ, H2AZ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C0S5
Gene
H2AZ1
Ensembl
ENSG00000164032
Chromosome
4
Canonical length
128 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>P0C0S5|H2AZ1
     1  MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE
    61  YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG
   121  KKGQQKTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
586 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 586 nTPM
  • thymus: 508 nTPM
  • tonsil: 361 nTPM
  • lymph node: 325 nTPM
  • esophagus: 246 nTPM
  • colon: 226 nTPM

Single-cell type

  • esophageal basal cells: 1,906 nCPM
  • extravillous trophoblasts: 1,622 nCPM
  • basal keratinocytes: 1,385 nCPM
  • migrating cytotrophoblasts: 1,125 nCPM
  • suprabasal keratinocytes: 1,017 nCPM
  • monocyte progenitors: 984 nCPM

Immune cell

  • total PBMC: 1,556 nTPM
  • neutrophil: 1,490 nTPM
  • eosinophil: 1,379 nTPM
  • non-classical monocyte: 1,058 nTPM
  • T-reg: 871 nTPM
  • intermediate monocyte: 790 nTPM

Brain region

  • cerebral cortex: 69 nTPM
  • basal ganglia: 66 nTPM
  • choroid plexus: 66 nTPM
  • hypothalamus: 64 nTPM
  • white matter: 62 nTPM
  • cerebellum: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2AZ1.

Disease | ImmuneIEDB

Conditions an epitope on H2AZ1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.88
DepMap mean gene effect
-0.65
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H2AZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AZ1 as an antibody target. Whether an autoantibody or antibody against H2AZ1 could matter depends on whether native H2AZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2AZ1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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