H2AC20

Protein identityUniProt · HPA

UniProt accession

Q16777

Gene

H2AC20

Ensembl

ENSG00000184260

Chromosome

1

Canonical length

129 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>Q16777|H2AC20
     1  MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YMAAVLEYLT
    61  AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK
   121  TESHKAKSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AC20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

24 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2AC20.

Disease | ImmuneIEDB

Conditions an epitope on H2AC20 was assayed in.

• rheumatoid arthritis B cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against H2AC20 are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 4

ReferencesPubMed · IEDB

Publications for H2AC20 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.59

gnomAD pLI

0.19

DepMap mean gene effect

-0.87

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• heterochromatin formation

Molecular functions

• DNA binding
• protein heterodimerization activity
• structural constituent of chromatin

Cellular components

• extracellular exosome
• nucleosome
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Histone H2A
• Core Histone H2A/H2B/H3 domain
• Histone-fold
• Histone H2A, C-terminal domain
• Histone H2A conserved site
• Core histone H2A/H2B/H3/H4 domain
• C-terminus of histone H2A

KeywordsUniProt

• Acetylation
• Chromosome
• Citrullination
• DNA-binding
• Hydroxylation
• Isopeptide bond
• Methylation
• Nucleosome core
• Nucleus
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of H2AC20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• H1-4
• H2BC26
• PINK1