Seroatlas · Human Serome Atlas

H2BC5

Histone H2B type 1-D

Also known as: H2B/b, H2B1D_HUMAN, H2BFB, HIST1H2BD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P58876
Gene
H2BC5
Ensembl
ENSG00000158373
Chromosome
6
Canonical length
126 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>P58876|H2BC5
     1  MPEPTKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
    61  GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
   121  KYTSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
161 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 161 nTPM
  • ovary: 115 nTPM
  • cervix: 108 nTPM
  • vagina: 107 nTPM
  • kidney: 98 nTPM
  • liver: 68 nTPM

Single-cell type

  • prostatic club cells: 450 nCPM
  • basal prostatic cells: 288 nCPM
  • platelets: 270 nCPM
  • colonocytes: 216 nCPM
  • esophageal apical cells: 209 nCPM
  • prostatic hillock cells: 202 nCPM

Immune cell

  • basophil: 41 nTPM
  • neutrophil: 28 nTPM
  • naive B-cell: 21 nTPM
  • plasmacytoid DC: 20 nTPM
  • eosinophil: 19 nTPM
  • memory B-cell: 14 nTPM

Brain region

  • cerebellum: 126 nTPM
  • choroid plexus: 111 nTPM
  • white matter: 93 nTPM
  • hypothalamus: 86 nTPM
  • pons: 80 nTPM
  • spinal cord: 80 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BC5.

Disease | ImmuneIEDB

Conditions an epitope on H2BC5 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
DepMap mean gene effect
-0.66
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H2BC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC5 as an antibody target. Whether an autoantibody or antibody against H2BC5 could matter depends on whether native H2BC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2BC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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