Seroatlas · Human Serome Atlas

H2BC20P

Putative histone H2B type 2-C

Also known as: H2B2C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DN03
Gene: H2BC20P
Canonical length: 193 aa

OverviewNCBI Gene

No narrative summary is available for H2BC20P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q6DN03|H2BC20P
     1  MPEPAKFAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKRVH PDTGIWCKAM
    61  GIMNSFLNDI FERIAGEASR LAHYNKRSTI TSRRSRRPCA CCCPASWPST PCPRAPRRSP
   121  STPAPSESLP GPGARSLPPS LPPRVAGCFV SKGSFQGHLT TSVKESFLCC QSQLMFLASR
   181  LVNFRRAHNT KHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC20P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BC20P.

Disease | ImmuneIEDB

Conditions an epitope on H2BC20P was assayed in.

rheumatoid arthritis B cell

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC20P as an antibody target. Whether an autoantibody or antibody against H2BC20P could matter depends on whether native H2BC20P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC20P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BC20P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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