Seroatlas · Human Serome Atlas

H2BC21

Histone H2B type 2-E

Also known as: H2B, H2B-GL105, H2B.1, H2B/q, H2B2E_HUMAN, H2BE, H2BFQ, HIST2H2BE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16778
Gene
H2BC21
Ensembl
ENSG00000184678
Chromosome
1
Canonical length
126 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>Q16778|H2BC21
     1  MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM
    61  GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
   121  KYTSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 93 nTPM
  • skin: 80 nTPM
  • vagina: 76 nTPM
  • heart muscle: 73 nTPM
  • retina: 63 nTPM
  • cervix: 62 nTPM

Single-cell type

  • platelets: 532 nCPM
  • syncytiotrophoblasts: 250 nCPM
  • epididymal principal cells: 244 nCPM
  • tuft cells: 173 nCPM
  • esophageal apical cells: 115 nCPM
  • parietal cells: 92 nCPM

Immune cell

  • neutrophil: 59 nTPM
  • basophil: 21 nTPM
  • non-classical monocyte: 12 nTPM
  • total PBMC: 10 nTPM
  • plasmacytoid DC: 9 nTPM
  • eosinophil: 8.2 nTPM

Brain region

  • white matter: 80 nTPM
  • medulla oblongata: 55 nTPM
  • spinal cord: 54 nTPM
  • basal ganglia: 51 nTPM
  • pons: 49 nTPM
  • choroid plexus: 49 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BC21.

Disease | ImmuneIEDB

Conditions an epitope on H2BC21 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against H2BC21 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for H2BC21 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

13 publications

Show 8 more

Reference: B cellIEDB

2 publications

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0.55
DepMap mean gene effect
-0.63
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H2BC21 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC21 as an antibody target. Whether an autoantibody or antibody against H2BC21 could matter depends on whether native H2BC21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC21 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BC21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2BC21. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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