H3-7
Histone H3-7
Also known as: H3-2, H3.7, H37_HUMAN, HIST2H3PS2, p06
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5TEC6
- Gene
- H3-7
- Ensembl
- ENSG00000273213
- Chromosome
- 1
- Canonical length
- 136 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Acrosome,Principal piece
OverviewNCBI Gene
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a member of the H3 family, but is found outside of the histone cluster. There is evidence that it is transcribed and has an intact CDS, but residue changes in the protein suggest that it may be on its way to becoming a psuedogene. [provided by RefSeq, Aug 2019]
Canonical amino-acid sequenceUniProt
136 residues, UniProt reviewed canonical sequence.
>Q5TEC6|H3-7
1 MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE
61 LLIRKLPFQR LVREIAQEFK TDLRFQSSAV MALQEAREAY LVGLFEDTNL CAIHAKRVTI
121 MPKDIQLVSR IRGERALocalizationUniProt · AlphaFold · HPA
Whether an antibody against H3-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- ovary: 24 nTPM
- stomach: 17 nTPM
- adrenal gland: 14 nTPM
- spleen: 11 nTPM
- prostate: 8.6 nTPM
- choroid plexus: 7.7 nTPM
Single-cell type
- microglia: 2.2 nCPM
- ovarian stromal cells: 2.1 nCPM
- mucous neck cells: 2 nCPM
- lacrimal acinar cells: 1.8 nCPM
- breast myoepithelial cells: 1.7 nCPM
- conjunctival goblet cells: 1 nCPM
Immune cell
- neutrophil: 9.8 nTPM
- non-classical monocyte: 1.7 nTPM
- intermediate monocyte: 1.1 nTPM
- NK-cell: 0.8 nTPM
- myeloid DC: 0.7 nTPM
- naive B-cell: 0.7 nTPM
Brain region
- cerebellum: 31 nTPM
- pons: 25 nTPM
- spinal cord: 25 nTPM
- white matter: 23 nTPM
- midbrain: 23 nTPM
- hypothalamus: 22 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about H3-7.
Disease | ImmuneIEDB
Conditions an epitope on H3-7 was assayed in.
- rheumatoid arthritis B cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads H3-7 as an antibody target. Whether an autoantibody or antibody against H3-7 could matter depends on whether native H3-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
H3-7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label H3-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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