H2BW2
Histone H2B type F-M
Also known as: H2BFM, H2BFM_HUMAN, H2BM
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0C1H6
- Gene
- H2BW2
- Ensembl
- ENSG00000101812
- Chromosome
- X
- Canonical length
- 154 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family. [provided by RefSeq, Nov 2015]
Canonical amino-acid sequenceUniProt
154 residues, UniProt reviewed canonical sequence.
>P0C1H6|H2BW2
1 MAAASAMAEA SSETTSEEGQ SIQEPKEANS TKAQKQKRRG CRGSRRRHAN RRGDSFGDSF
61 TPYFPRVLKQ VHQGLSLSQE AVSVMDSMIH DILDRIATEA GQLAHYTKRV TITSRDIQMA
121 VRLLLPGKMG KLAEAQGTNA ALRTSLCAIW QQRKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against H2BW2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 2.6 nTPM
Expression across tissuesHPA
Tissue
- testis: 2.6 nTPM
- ovary: 1.9 nTPM
- thymus: 1.8 nTPM
- endometrium: 0.9 nTPM
- smooth muscle: 0.9 nTPM
- lymph node: 0.7 nTPM
Single-cell type
- late spermatids: 15 nCPM
- early primary spermatocytes: 11 nCPM
- late primary spermatocytes: 10 nCPM
- early spermatids: 6.7 nCPM
- thymocytes: 0.8 nCPM
- undifferentiated spermatogonia: 0.4 nCPM
Immune cell
- basophil: 0.4 nTPM
- NK-cell: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebellum: 2.8 nTPM
- cerebral cortex: 1.1 nTPM
- pons: 1.1 nTPM
- hypothalamus: 1 nTPM
- amygdala: 0.9 nTPM
- basal ganglia: 0.9 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about H2BW2.
Disease | ImmuneIEDB
Conditions an epitope on H2BW2 was assayed in.
- rheumatoid arthritis B cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.64
- gnomAD pLI
- 0.01
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads H2BW2 as an antibody target. Whether an autoantibody or antibody against H2BW2 could matter depends on whether native H2BW2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
H2BW2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label H2BW2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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