H2AC25
Histone H2A type 3
Also known as: H2A3_HUMAN, H2AW, HIST3H2A, MGC3165
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q7L7L0
- Gene
- H2AC25
- Ensembl
- ENSG00000181218
- Chromosome
- 1
- Canonical length
- 130 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Canonical amino-acid sequenceUniProt
130 residues, UniProt reviewed canonical sequence.
>Q7L7L0|H2AC25
1 MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT
61 AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK
121 TESHHKAKGKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against H2AC25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 76 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 76 nTPM
- adrenal gland: 34 nTPM
- vagina: 22 nTPM
- choroid plexus: 21 nTPM
- basal ganglia: 20 nTPM
- cervix: 18 nTPM
Single-cell type
- brain excitatory neurons: 13 nCPM
- microglia: 11 nCPM
- brain inhibitory neurons: 8.9 nCPM
- other brain neurons: 7.8 nCPM
- choroid plexus epithelial cells: 4.1 nCPM
- oligodendrocytes: 4.1 nCPM
Immune cell
- T-reg: 14 nTPM
- non-classical monocyte: 9.2 nTPM
- NK-cell: 8.8 nTPM
- gdT-cell: 7.9 nTPM
- memory CD4 T-cell: 6.8 nTPM
- memory CD8 T-cell: 5.8 nTPM
Brain region
- cerebellum: 43 nTPM
- hypothalamus: 29 nTPM
- cerebral cortex: 23 nTPM
- choroid plexus: 21 nTPM
- basal ganglia: 21 nTPM
- pons: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0.53
- DepMap mean gene effect
- -0.33
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads H2AC25 as an antibody target. Whether an autoantibody or antibody against H2AC25 could matter depends on whether native H2AC25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
H2AC25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label H2AC25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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