Seroatlas · Human Serome Atlas

SRPK2

SRSF protein kinase 2

Also known as: SFRSK2, SRPK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78362
Gene
SRPK2
Ensembl
ENSG00000135250
Chromosome
7
Canonical length
688 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Cytosol,Acrosome,End piece

OverviewNCBI Gene

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including R-loop processing; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

688 residues, UniProt reviewed canonical sequence.

>P78362|SRPK2
     1  MSVNSEKSSS SERPEPQQKA PLVPPPPPPP PPPPPPLPDP TPPEPEEEIL GSDDEEQEDP
    61  ADYCKGGYHP VKIGDLFNGR YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE
   121  TALDEIKLLK CVRESDPSDP NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS
   181  NYQGLPVRCV KSIIRQVLQG LDYLHSKCKI IHTDIKPENI LMCVDDAYVR RMAAEATEWQ
   241  KAGAPPPSGS AVSTAPQQKP IGKISKNKKK KLKKKQKRQA ELLEKRLQEI EELEREAERK
   301  IIEENITSAA PSNDQDGEYC PEVKLKTTGL EEAAEAETAK DNGEAEDQEE KEDAEKENIE
   361  KDEDDVDQEL ANIDPTWIES PKTNGHIENG PFSLEQQLDD EDDDEEDCPN PEEYNLDEPN
   421  AESDYTYSSS YEQFNGELPN GRHKIPESQF PEFSTSLFSG SLEPVACGSV LSEGSPLTEQ
   481  EESSPSHDRS RTVSASSTGD LPKAKTRAAD LLVNPLDPRN ADKIRVKIAD LGNACWVHKH
   541  FTEDIQTRQY RSIEVLIGAG YSTPADIWST ACMAFELATG DYLFEPHSGE DYSRDEDHIA
   601  HIIELLGSIP RHFALSGKYS REFFNRRGEL RHITKLKPWS LFDVLVEKYG WPHEDAAQFT
   661  DFLIPMLEMV PEKRASAGEC LRHPWLNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRPK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • testis: 88 nTPM
  • cerebral cortex: 56 nTPM
  • thymus: 36 nTPM
  • hypothalamus: 33 nTPM
  • cerebellum: 32 nTPM
  • midbrain: 31 nTPM

Single-cell type

  • late spermatids: 3,787 nCPM
  • neutrophils: 2,231 nCPM
  • early spermatids: 1,649 nCPM
  • sertoli cells: 1,647 nCPM
  • late primary spermatocytes: 870 nCPM
  • choroid plexus epithelial cells: 625 nCPM

Immune cell

  • neutrophil: 90 nTPM
  • eosinophil: 54 nTPM
  • NK-cell: 24 nTPM
  • basophil: 23 nTPM
  • T-reg: 23 nTPM
  • gdT-cell: 21 nTPM

Brain region

  • white matter: 137 nTPM
  • cerebral cortex: 107 nTPM
  • basal ganglia: 102 nTPM
  • pons: 100 nTPM
  • midbrain: 98 nTPM
  • thalamus: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
2.81
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRPK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRPK2 as an antibody target. Whether an autoantibody or antibody against SRPK2 could matter depends on whether native SRPK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRPK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRPK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRPK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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