Seroatlas · Human Serome Atlas

SNIP1

Smad nuclear-interacting protein 1

Also known as: PML1, SNIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAD8
Gene
SNIP1
Ensembl
ENSG00000163877
Chromosome
1
Canonical length
396 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>Q8TAD8|SNIP1
     1  MKAVKSERER GSRRRHRDGD VVLPAGVVVK QERLSPEVAP PAHRRPDHSG GSPSPPTSEP
    61  ARSGHRGNRA RGVSRSPPKK KNKASGRRSK SPRSKRNRSP HHSTVKVKQE REDHPRRGRE
   121  DRQHREPSEQ EHRRARNSDR DRHRGHSHQR RTSNERPGSG QGQGRDRDTQ NLQAQEEERE
   181  FYNARRREHR QRNDVGGGGS ESQELVPRPG GNNKEKEVPA KEKPSFELSG ALLEDTNTFR
   241  GVVIKYSEPP EARIPKKRWR LYPFKNDEVL PVMYIHRQSA YLLGRHRRIA DIPIDHPSCS
   301  KQHAVFQYRL VEYTRADGTV GRRVKPYIID LGSGNGTFLN NKRIEPQRYY ELKEKDVLKF
   361  GFSSREYVLL HESSDTSEID RKDDEDEEEE EEVSDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
5.9 nTPM

Expression across tissuesHPA

Tissue

  • liver: 5.9 nTPM
  • bone marrow: 5.2 nTPM
  • testis: 4.3 nTPM
  • breast: 4.1 nTPM
  • esophagus: 3.9 nTPM
  • tonsil: 3.9 nTPM

Single-cell type

  • neutrophils: 107 nCPM
  • endometrial glandular cells: 106 nCPM
  • endometrial luminal cells: 87 nCPM
  • ocular epithelial cells: 73 nCPM
  • breast lactating cells: 65 nCPM
  • endometrial ciliated cells: 56 nCPM

Immune cell

  • gdT-cell: 1.5 nTPM
  • MAIT T-cell: 1.5 nTPM
  • memory CD8 T-cell: 1.5 nTPM
  • basophil: 1.4 nTPM
  • naive CD4 T-cell: 1.3 nTPM
  • eosinophil: 1.2 nTPM

Brain region

  • cerebellum: 7.6 nTPM
  • white matter: 6.6 nTPM
  • hypothalamus: 6.5 nTPM
  • cerebral cortex: 6.3 nTPM
  • thalamus: 6.1 nTPM
  • hippocampal formation: 6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNIP1.

Disease | AllUniProt

Conditions SNIP1 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with hypotonia, craniofacial abnormalities, and seizures (NEDHCS) MIM:614501

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 274 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Psychomotor retardation, epilepsy, and craniofacial dysmorphism

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.42
gnomAD missense Z
1.24
DepMap mean gene effect
-0.59
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNIP1 as an antibody target. Whether an autoantibody or antibody against SNIP1 could matter depends on whether native SNIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...