Seroatlas · Human Serome Atlas

LUC7L2

Putative RNA-binding protein Luc7-like 2

Also known as: CGI-59, CGI-74, FLJ10657, H_NH0792N18.3, hLuc7B2, LC7L2_HUMAN, LUC7B2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y383
Gene
LUC7L2
Ensembl
ENSG00000146963
Chromosome
7
Canonical length
392 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q9Y383|LUC7L2
     1  MSAQAQMRAM LDQLMGTSRD GDTTRQRIKF SDDRVCKSHL LNCCPHDVLS GTRMDLGECL
    61  KVHDLALRAD YEIASKEQDF FFELDAMDHL QSFIADCDRR TEVAKKRLAE TQEEISAEVA
   121  AKAERVHELN EEIGKLLAKV EQLGAEGNVE ESQKVMDEVE KARAKKREAE EVYRNSMPAS
   181  SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIE IREKLEELKR VVAEKQEKRN
   241  QERLKRREER EREEREKLRR SRSHSKNPKR SRSREHRRHR SRSMSRERKR RTRSKSREKR
   301  HRHRSRSSSR SRSRSHQRSR HSSRDRSRER SKRRSSKERF RDQDLASCDR DRSSRDRSPR
   361  DRDRKDKKRS YESANGRSED RRSSEEREAG EI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LUC7L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 75 nTPM
  • skeletal muscle: 60 nTPM
  • thymus: 58 nTPM
  • thyroid gland: 57 nTPM
  • blood vessel: 56 nTPM
  • spinal cord: 51 nTPM

Single-cell type

  • oligodendrocytes: 315 nCPM
  • bergmann glia: 248 nCPM
  • brain excitatory neurons: 244 nCPM
  • brain inhibitory neurons: 235 nCPM
  • choroid plexus epithelial cells: 228 nCPM
  • other brain neurons: 224 nCPM

Immune cell

  • naive CD4 T-cell: 21 nTPM
  • MAIT T-cell: 20 nTPM
  • T-reg: 19 nTPM
  • memory CD8 T-cell: 19 nTPM
  • naive CD8 T-cell: 18 nTPM
  • eosinophil: 18 nTPM

Brain region

  • white matter: 78 nTPM
  • cerebral cortex: 77 nTPM
  • hypothalamus: 72 nTPM
  • cerebellum: 63 nTPM
  • thalamus: 61 nTPM
  • basal ganglia: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
2.19
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LUC7L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LUC7L2 as an antibody target. Whether an autoantibody or antibody against LUC7L2 could matter depends on whether native LUC7L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LUC7L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LUC7L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LUC7L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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