Seroatlas · Human Serome Atlas

CHTOP

Chromatin target of PRMT1 protein

Also known as: C1orf77, CHTOP_HUMAN, DKFZP547E1010, FOP, SRAG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3Y2
Gene
CHTOP
Ensembl
ENSG00000160679
Chromosome
1
Canonical length
248 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q9Y3Y2|CHTOP
     1  MAAQSAPKVV LKSTTKMSLN ERFTNMLKNK QPTPVNIRAS MQQQQQLASA RNRRLAQQME
    61  NRPSVQAALK LKQSLKQRLG KSNIQARLGR PIGALARGAI GGRGLPIIQR GLPRGGLRGG
   121  RATRTLLRGG MSLRGQNLLR GGRAVAPRMG LRRGGVRGRG GPGRGGLGRG AMGRGGIGGR
   181  GRGMIGRGRG GFGGRGRGRG RGRGALARPV LTKEQLDNQL DAYMSKTKGH LDAELDAYMA
   241  QTDPETND

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHTOP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
117 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 117 nTPM
  • tongue: 64 nTPM
  • spleen: 63 nTPM
  • thymus: 61 nTPM
  • cerebellum: 61 nTPM
  • pancreas: 61 nTPM

Single-cell type

  • esophageal apical cells: 168 nCPM
  • syncytiotrophoblasts: 152 nCPM
  • extravillous trophoblasts: 146 nCPM
  • early primary spermatocytes: 138 nCPM
  • oocytes: 129 nCPM
  • esophageal suprabasal cells: 128 nCPM

Immune cell

  • basophil: 85 nTPM
  • myeloid DC: 54 nTPM
  • T-reg: 52 nTPM
  • memory B-cell: 46 nTPM
  • total PBMC: 46 nTPM
  • MAIT T-cell: 46 nTPM

Brain region

  • white matter: 70 nTPM
  • cerebellum: 53 nTPM
  • basal ganglia: 51 nTPM
  • medulla oblongata: 48 nTPM
  • hypothalamus: 45 nTPM
  • pons: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.76
gnomAD missense Z
1.7
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHTOP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHTOP as an antibody target. Whether an autoantibody or antibody against CHTOP could matter depends on whether native CHTOP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHTOP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHTOP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHTOP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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