Seroatlas · Human Serome Atlas

SNRNP27

U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

Also known as: RY1, SNR27_HUMAN, U4/U6.U5-27K

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WVK2
Gene
SNRNP27
Ensembl
ENSG00000124380
Chromosome
2
Canonical length
155 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>Q8WVK2|SNRNP27
     1  MGRSRSRSPR RERRRSRSTS RERERRRRER SRSRERDRRR SRSRSPHRRR SRSPRRHRST
    61  SPSPSRLKER RDEEKKETKE TKSKERQITE EDLEGKTEEE IEMMKLMGFA SFDSTKGKKV
   121  DGSVNAYAIN VSQKRKYRQY MNRKGGFNRP LDFIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRNP27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
67 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 67 nTPM
  • skeletal muscle: 58 nTPM
  • bone marrow: 41 nTPM
  • heart muscle: 37 nTPM
  • spinal cord: 37 nTPM
  • amygdala: 34 nTPM

Single-cell type

  • tuft cells: 161 nCPM
  • megakaryocytes: 80 nCPM
  • hepatocytes: 64 nCPM
  • parietal cells: 60 nCPM
  • early primary spermatocytes: 51 nCPM
  • late primary spermatocytes: 49 nCPM

Immune cell

  • basophil: 43 nTPM
  • plasmacytoid DC: 41 nTPM
  • eosinophil: 39 nTPM
  • memory B-cell: 38 nTPM
  • naive B-cell: 32 nTPM
  • NK-cell: 32 nTPM

Brain region

  • white matter: 42 nTPM
  • cerebral cortex: 39 nTPM
  • cerebellum: 37 nTPM
  • hypothalamus: 37 nTPM
  • midbrain: 35 nTPM
  • basal ganglia: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
1.76
DepMap mean gene effect
-1.08
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
  • U4/U6.U5 small nuclear ribonucleoproteins

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRNP27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRNP27 as an antibody target. Whether an autoantibody or antibody against SNRNP27 could matter depends on whether native SNRNP27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRNP27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRNP27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNRNP27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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