Seroatlas · Human Serome Atlas

CDK7

Cyclin-dependent kinase 7

Also known as: CAK, CAK1, CDK7_HUMAN, CDKN7, MO15, STK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50613
Gene: CDK7
Ensembl: ENSG00000134058
Chromosome: 5
Canonical length: 346 aa
Protein class: Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>P50613|CDK7
     1  MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL
    61  REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM
   121  TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA
   181  PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM
   241  CSLPDYVTFK SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG
   301  PTPGCQLPRP NCPVETLKEQ SNPALAIKRK RTEALEQGGL PKKLIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

esophagus: 36 nTPM
testis: 29 nTPM
bone marrow: 27 nTPM
skeletal muscle: 26 nTPM
skin: 24 nTPM
vagina: 20 nTPM

Single-cell type

extravillous trophoblasts: 381 nCPM
oocytes: 175 nCPM
migrating cytotrophoblasts: 172 nCPM
esophageal apical cells: 142 nCPM
cytotrophoblasts: 109 nCPM
late primary spermatocytes: 101 nCPM

Immune cell

basophil: 28 nTPM
eosinophil: 16 nTPM
naive B-cell: 15 nTPM
memory B-cell: 11 nTPM
memory CD8 T-cell: 11 nTPM
T-reg: 11 nTPM

Brain region

choroid plexus: 12 nTPM
cerebellum: 11 nTPM
hypothalamus: 10 nTPM
cerebral cortex: 9.6 nTPM
basal ganglia: 9.4 nTPM
thalamus: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 1.94
DepMap mean gene effect: -1.77
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
ATP-dependent activity, acting on DNA
cyclin-dependent protein serine/threonine kinase activity
protein kinase activity
protein serine kinase activity
protein serine/threonine kinase activity
RNA polymerase II CTD heptapeptide repeat kinase activity
RNA polymerase II CTD heptapeptide repeat S5 kinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK7 as an antibody target. Whether an autoantibody or antibody against CDK7 could matter depends on whether native CDK7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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