Seroatlas · Human Serome Atlas

FXR2

RNA-binding protein FXR2

Also known as: FMR1L2, FXR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51116
Gene: FXR2
Ensembl: ENSG00000129245
Chromosome: 17
Canonical length: 673 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>P51116|FXR2
     1  MGGLASGGDV EPGLPVEVRG SNGAFYKGFV KDVHEDSVTI FFENNWQSER QIPFGDVRLP
    61  PPADYNKEIT EGDEVEVYSR ANEQEPCGWW LARVRMMKGD FYVIEYAACD ATYNEIVTLE
   121  RLRPVNPNPL ATKGSFFKVT MAVPEDLREA CSNENVHKEF KKALGANCIF LNITNSELFI
   181  LSTTEAPVKR ASLLGDMHFR SLRTKLLLMS RNEEATKHLE TSKQLAAAFQ EEFTVREDLM
   241  GLAIGTHGAN IQQARKVPGV TAIELGEETC TFRIYGETPE ACRQARSYLE FSEDSVQVPR
   301  NLVGKVIGKN GKVIQEIVDK SGVVRVRVEG DNDKKNPREE GMVPFIFVGT RENISNAQAL
   361  LEYHLSYLQE VEQLRLERLQ IDEQLRQIGL GFRPPGSGRG SGGSDKAGYS TDESSSSSLH
   421  ATRTYGGSYG GRGRGRRTGG PAYGPSSDVS TASETESEKR EEPNRAGPGD RDPPTRGEES
   481  RRRPTGGRGR GPPPAPRPTS RYNSSSISSV LKDPDSNPYS LLDTSEPEPP VDSEPGEPPP
   541  ASARRRRSRR RRTDEDRTVM DGGLESDGPN MTENGLEDES RPQRRNRSRR RRNRGNRTDG
   601  SISGDRQPVT VADYISRAES QSRQRPPLER TKPSEDSLSG QKGDSVSKLP KGPSENGELS
   661  APLELGSMVN GVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FXR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 113 nTPM
tongue: 79 nTPM
heart muscle: 61 nTPM
cerebellum: 46 nTPM
cerebral cortex: 41 nTPM
midbrain: 39 nTPM

Single-cell type

thymic myoid cells: 56 nCPM
retinal pigment epithelial cells: 43 nCPM
cardiomyocytes: 41 nCPM
retinal horizontal cells: 38 nCPM
early primary spermatocytes: 37 nCPM
rod photoreceptor cells: 33 nCPM

Immune cell

basophil: 2.6 nTPM
eosinophil: 2.5 nTPM
neutrophil: 2.1 nTPM
memory CD8 T-cell: 1.9 nTPM
T-reg: 1.8 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

pons: 76 nTPM
midbrain: 71 nTPM
medulla oblongata: 70 nTPM
hypothalamus: 68 nTPM
cerebral cortex: 62 nTPM
thalamus: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.62
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

K Homology domain
K Homology domain, type 1
Agenet-like domain
Fragile X messenger ribonucleoprotein 1-like, C-terminal core
Fragile X-related protein 1, C-terminal region 1
K Homology domain, type 1 superfamily
Fragile X messenger ribonucleoprotein 1
Synaptic functional regulator FMRP, KH0 domain
FMR1, tudor domain
KH domain
Agenet domain
Fragile X-related 1 protein core C terminal
Fragile X-related 1 protein C-terminal region 2
FMRP KH0 domain
Fragile X messenger ribonucleoprotein 1, Tudor domain
RNA-binding protein FXR2, second Tudor-like Agenet domain
RNA-binding protein FXR2, first Tudor-like Agenet domain
RNA-binding protein FXR2, first type I K homology domain
RNA-binding protein FXR2, second type I K homology domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FXR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FXR2 as an antibody target. Whether an autoantibody or antibody against FXR2 could matter depends on whether native FXR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FXR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FXR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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