YWHAB
14-3-3 protein beta/alpha
Also known as: 1433B_HUMAN, YWHAA
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P31946
- Gene
- YWHAB
- Ensembl
- ENSG00000166913
- Chromosome
- 20
- Canonical length
- 246 aa
- Protein class
- Cancer-related genes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
246 residues, UniProt reviewed canonical sequence.
>P31946|YWHAB
1 MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS
61 WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY
121 LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY
181 YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD
241 AGEGENLocalizationUniProt · AlphaFold · HPA
Whether an antibody against YWHAB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 254 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 254 nTPM
- tonsil: 197 nTPM
- hippocampal formation: 166 nTPM
- lymph node: 163 nTPM
- rectum: 163 nTPM
- basal ganglia: 159 nTPM
Single-cell type
- esophageal apical cells: 1,215 nCPM
- extravillous trophoblasts: 807 nCPM
- esophageal suprabasal cells: 776 nCPM
- neutrophils: 714 nCPM
- neutrophil progenitors: 661 nCPM
- syncytiotrophoblasts: 623 nCPM
Immune cell
- non-classical monocyte: 156 nTPM
- intermediate monocyte: 131 nTPM
- T-reg: 114 nTPM
- basophil: 106 nTPM
- myeloid DC: 103 nTPM
- classical monocyte: 95 nTPM
Brain region
- cerebral cortex: 313 nTPM
- hippocampal formation: 302 nTPM
- hypothalamus: 288 nTPM
- basal ganglia: 286 nTPM
- thalamus: 243 nTPM
- white matter: 227 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.24
- gnomAD pLI
- 0.98
- gnomAD missense Z
- 1.89
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- intracellular protein localization
- negative regulation of cell growth involved in contact inhibition
- negative regulation of DNA-templated transcription
- negative regulation of G protein-coupled receptor signaling pathway
- negative regulation of protein import into nucleus
- positive regulation of hippo signaling
- positive regulation of transcription by RNA polymerase II
- protein targeting
- signal transduction
Molecular functions
- cadherin binding
- enzyme binding
- histone deacetylase binding
- identical protein binding
- phosphoprotein binding
- phosphoserine residue binding
- protein domain specific binding
- protein kinase inhibitor activity
- protein phosphatase inhibitor activity
- protein sequestering activity
- protein-containing complex binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of YWHAB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads YWHAB as an antibody target. Whether an autoantibody or antibody against YWHAB could matter depends on whether native YWHAB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
YWHAB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label YWHAB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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