Seroatlas · Human Serome Atlas

LUC7L

Putative RNA-binding protein Luc7-like 1

Also known as: hLuc7B1, Luc7, LUC7B1, LUC7L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQ29
Gene: LUC7L
Ensembl: ENSG00000007392
Chromosome: 16
Canonical length: 371 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q9NQ29|LUC7L
     1  MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA GTRMDLGECT
    61  KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR TELAKKRLAE TQEEISAEVS
   121  AKAEKVHELN EEIGKLLAKA EQLGAEGNVD ESQKILMEVE KVRAKKKEAE EEYRNSMPAS
   181  SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN
   241  QDRLRRREER EREERLSRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKL SRSRSRDRHR
   301  RHRSRSRSHS RGHRRASRDR SAKYKFSRER ASREESWESG RSERGPPDWR LESSNGKMAS
   361  RRSEEKEAGE I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LUC7L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 73 nTPM
cerebellum: 70 nTPM
prostate: 69 nTPM
hippocampal formation: 67 nTPM
spleen: 63 nTPM
pituitary gland: 62 nTPM

Single-cell type

myonuclei: 173 nCPM
lactotrophs: 149 nCPM
somatotrophs: 140 nCPM
pituicytes/fscs: 135 nCPM
thyrotrophs: 130 nCPM
retinal ganglion cells: 128 nCPM

Immune cell

non-classical monocyte: 13 nTPM
plasmacytoid DC: 12 nTPM
intermediate monocyte: 11 nTPM
myeloid DC: 10 nTPM
classical monocyte: 9.4 nTPM
T-reg: 7.6 nTPM

Brain region

cerebral cortex: 25 nTPM
white matter: 22 nTPM
cerebellum: 21 nTPM
hypothalamus: 20 nTPM
hippocampal formation: 19 nTPM
choroid plexus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.47
gnomAD missense Z: 1.88
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LUC7L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LUC7L as an antibody target. Whether an autoantibody or antibody against LUC7L could matter depends on whether native LUC7L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LUC7L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LUC7L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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