Seroatlas · Human Serome Atlas

RSRC2

Arginine/serine-rich coiled-coil protein 2

Also known as: FLJ11021, RSRC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L4I2
Gene: RSRC2
Ensembl: ENSG00000111011
Chromosome: 12
Canonical length: 434 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Nuclear speckles,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q7L4I2|RSRC2
     1  MAASDTERDG LAPEKTSPDR DKKKEQSEVS VSPRASKHHY SRSRSRSRER KRKSDNEGRK
    61  HRSRSRSKEG RRHESKDKSS KKHKSEEHND KEHSSDKGRE RLNSSENGED RHKRKERKSS
   121  RGRSHSRSRS RERRHRSRSR ERKKSRSRSR ERKKSRSRSR ERKKSRSRSR ERKRRIRSRS
   181  RSRSRHRHRT RSRSRTRSRS RDRKKRIEKP RRFSRSLSRT PSPPPFRGRN TAMDAQEALA
   241  RRLERAKKLQ EQREKEMVEK QKQQEIAAAA ATGGSVLNVA ALLASGTQVT PQIAMAAQMA
   301  ALQAKALAET GIAVPSYYNP AAVNPMKFAE QEKKRKMLWQ GKKEGDKSQS AEIWEKLNFG
   361  NKDQNVKFRK LMGIKSEDEA GCSSVDEESY KTLKQQEEVF RNLDAQYEMA RSQTHTQRGM
   421  GLGFTSSMRG MDAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RSRC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 62 nTPM
skeletal muscle: 26 nTPM
cerebellum: 20 nTPM
esophagus: 16 nTPM
blood vessel: 16 nTPM
ovary: 16 nTPM

Single-cell type

esophageal apical cells: 450 nCPM
syncytiotrophoblasts: 399 nCPM
late primary spermatocytes: 310 nCPM
epididymal efferent duct absorptive cells: 291 nCPM
early spermatids: 290 nCPM
extravillous trophoblasts: 288 nCPM

Immune cell

naive B-cell: 34 nTPM
memory B-cell: 29 nTPM
basophil: 27 nTPM
eosinophil: 26 nTPM
non-classical monocyte: 23 nTPM
T-reg: 22 nTPM

Brain region

cerebellum: 36 nTPM
cerebral cortex: 33 nTPM
hypothalamus: 31 nTPM
midbrain: 28 nTPM
white matter: 27 nTPM
medulla oblongata: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RSRC2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

6 conditions

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 1.99
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RSRC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SRPK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RSRC2 as an antibody target. Whether an autoantibody or antibody against RSRC2 could matter depends on whether native RSRC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RSRC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RSRC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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