Seroatlas · Human Serome Atlas

ARL6IP4

ADP-ribosylation factor-like protein 6-interacting protein 4

Also known as: AR6P4_HUMAN, SFRS20, SR-25, SRp25, SRrp37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q66PJ3
Gene: ARL6IP4
Ensembl: ENSG00000182196
Chromosome: 12
Canonical length: 237 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in RNA splicing. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q66PJ3|ARL6IP4
     1  MAHVGSRKRS RSRSRSRGRG SEKRKKKSRK DTSRNCSAST SQGRKASTAP GAEASPSPCI
    61  TERSKQKARR RTRSSSSSSS SSSSSSSSSS SSSSSSSSDG RKKRGKYKDK RRKKKKKRKK
   121  LKKKGKEKAE AQQVEALPGP SLDQWHRSAG EEEDGPVLTD EQKSRIQAMK PMTKEEWDAR
   181  QSIIRKVVDP ETGRTRLIKG DGEVLEEIVT KERHREINKQ ATRGDCLAFQ MRAGLLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARL6IP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 367 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 367 nTPM
amygdala: 269 nTPM
liver: 254 nTPM
blood vessel: 243 nTPM
cerebral cortex: 220 nTPM
pancreas: 219 nTPM

Single-cell type

enterocytes: 176 nCPM
colonocytes: 114 nCPM
enteric transient amplifying cells: 93 nCPM
gastric chief cells: 76 nCPM
epididymal efferent duct absorptive cells: 75 nCPM
neuroendocrine cells: 75 nCPM

Immune cell

non-classical monocyte: 475 nTPM
intermediate monocyte: 406 nTPM
myeloid DC: 383 nTPM
total PBMC: 364 nTPM
T-reg: 343 nTPM
eosinophil: 325 nTPM

Brain region

cerebral cortex: 114 nTPM
thalamus: 102 nTPM
white matter: 101 nTPM
medulla oblongata: 99 nTPM
amygdala: 98 nTPM
midbrain: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: -0.81

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear RNA-splicing-associated protein, SR-25
Nuclear RNA-splicing-associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARL6IP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARL6IP4 as an antibody target. Whether an autoantibody or antibody against ARL6IP4 could matter depends on whether native ARL6IP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARL6IP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARL6IP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...