Seroatlas · Human Serome Atlas

NSRP1

Nuclear speckle splicing regulatory protein 1

Also known as: CCDC55, DKFZP434K1421, NSRP1_HUMAN, NSrp70

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0G5
Gene: NSRP1
Ensembl: ENSG00000126653
Chromosome: 17
Canonical length: 558 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables mRNA binding activity. Involved in developmental process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

558 residues, UniProt reviewed canonical sequence.

>Q9H0G5|NSRP1
     1  MAIPGRQYGL ILPKKTQQLH PVLQKPSVFG NDSDDDDETS VSESLQREAA KKQAMKQTKL
    61  EIQKALAEDA TVYEYDSIYD EMQKKKEENN PKLLLGKDRK PKYIHNLLKA VEIRKKEQEK
   121  RMEKKIQRER EMEKGEFDDK EAFVTSAYKK KLQERAEEEE REKRAAALEA CLDVTKQKDL
   181  SGFYRHLLNQ AVGEEEVPKC SFREARSGIK EEKSRGFSNE VSSKNRIPQE KCILQTDVKV
   241  EENPDADSDF DAKSSADDEI EETRVNCRRE KVIETPENDF KHHRSQNHSR SPSEERGHST
   301  RHHTKGSRTS RGHEKREDQH QQKQSRDQEN HYTDRDYRKE RDSHRHREAS HRDSHWKRHE
   361  QEDKPRARDQ RERSDRVWKR EKDREKYSQR EQERDRQQND QNRPSEKGEK EEKSKAKEEH
   421  MKVRKERYEN NDKYRDREKR EVGVQSSERN QDRKESSPNS RAKDKFLDQE RSNKMRNMAK
   481  DKERNQEKPS NSESSLGAKH RLTEEGQEKG KEQERPPEAV SKFAKRNNEE TVMSARDRYL
   541  ARQMARVNAK TYIEKEDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSRP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 39 nTPM
blood vessel: 34 nTPM
midbrain: 34 nTPM
skeletal muscle: 25 nTPM
choroid plexus: 24 nTPM
colon: 24 nTPM

Single-cell type

late primary spermatocytes: 258 nCPM
early spermatids: 227 nCPM
early primary spermatocytes: 222 nCPM
myonuclei: 201 nCPM
hepatocytes: 199 nCPM
sertoli cells: 192 nCPM

Immune cell

basophil: 67 nTPM
plasmacytoid DC: 63 nTPM
memory B-cell: 62 nTPM
neutrophil: 62 nTPM
naive B-cell: 58 nTPM
non-classical monocyte: 45 nTPM

Brain region

white matter: 83 nTPM
cerebellum: 80 nTPM
choroid plexus: 77 nTPM
medulla oblongata: 75 nTPM
hypothalamus: 71 nTPM
basal ganglia: 70 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NSRP1.

Disease | AllUniProt

Conditions NSRP1 is implicated in, by any mechanism.

Neurodevelopmental disorder with spasticity, seizures, and brain abnormalities (NEDSSBA) MIM:620001

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with spasticity, seizures, and brain abnormalities
Microcephaly
Seizure
Spasticity
Severe global developmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.01
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.53
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear speckle splicing regulatory protein 1, N-terminal
Nuclear speckle splicing regulatory protein 1
Nuclear speckle splicing regulatory protein 1, RS-like domain
Nuclear speckle splicing regulatory protein 1, N-terminal
Nuclear speckle splicing regulatory protein 1, RS-like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NSRP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSRP1 as an antibody target. Whether an autoantibody or antibody against NSRP1 could matter depends on whether native NSRP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSRP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSRP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...