Seroatlas · Human Serome Atlas

SFN

14-3-3 protein sigma

Also known as: 1433S_HUMAN, YWHAS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P31947
Gene: SFN
Ensembl: ENSG00000175793
Chromosome: 1
Canonical length: 248 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Cytosol,Mid piece
Secretome location: Secreted in other tissues
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>P31947|SFN
     1  MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR
    61  VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY
   121  LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH
   181  YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG
   241  EAPQEPQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 2,405 nTPM

Expression across tissuesHPA

Tissue

esophagus: 2,405 nTPM
skin: 1,183 nTPM
vagina: 678 nTPM
cervix: 466 nTPM
salivary gland: 315 nTPM
urinary bladder: 156 nTPM

Single-cell type

suprabasal keratinocytes: 10,596 nCPM
esophageal suprabasal cells: 10,491 nCPM
esophageal apical cells: 8,731 nCPM
basal keratinocytes: 6,518 nCPM
esophageal basal cells: 4,503 nCPM
ocular epithelial cells: 3,989 nCPM

Immune cell

basophil: 5.9 nTPM
T-reg: 0.3 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 21 nTPM
medulla oblongata: 19 nTPM
thalamus: 12 nTPM
midbrain: 9.4 nTPM
pons: 9.3 nTPM
white matter: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.37
gnomAD missense Z: 1.4
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFN as an antibody target. Whether an autoantibody or antibody against SFN could matter depends on whether native SFN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFN is annotated as secreted, so native SFN circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SFN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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