Seroatlas · Human Serome Atlas

SRRM1

Serine/arginine repetitive matrix protein 1

Also known as: MGC39488, POP101, SRM160, SRRM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYB3
Gene: SRRM1
Ensembl: ENSG00000133226
Chromosome: 1
Canonical length: 904 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Part of catalytic step 2 spliceosome. Biomarker of gestational diabetes. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q8IYB3|SRRM1
     1  MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP WITKRVTEIL
    61  GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE FMGELWPLLL SAQENIAGIP
   121  SAFLELKKEE IKQRQIEQEK LASMKKQDED KDKRDKEEKE SSREKRERSR SPRRRKSRSP
   181  SPRRRSSPVR RERKRSHSRS PRHRTKSRSP SPAPEKKEKT PELPEPSVKV KEPSVQEATS
   241  TSDILKVPKP EPIPEPKEPS PEKNSKKEKE KEKTRPRSRS RSKSRSRTRS RSPSHTRPRR
   301  RHRSRSRSYS PRRRPSPRRR PSPRRRTPPR RMPPPPRHRR SRSPVRRRRR SSASLSGSSS
   361  SSSSSRSRSP PKKPPKRTSS PPRKTRRLSP SASPPRRRHR PSPPATPPPK TRHSPTPQQS
   421  NRTRKSRVSV SPGRTSGKVT KHKGTEKRES PSPAPKPRKV ELSESEEDKG GKMAAADSVQ
   481  QRRQYRRQNQ QSSSDSGSSS SSEDERPKRS HVKNGEVGRR RRHSPSRSAS PSPRKRQKET
   541  SPRGRRRRSP SPPPTRRRRS PSPAPPPRRR RTPTPPPRRR TPSPPPRRRS PSPRRYSPPI
   601  QRRYSPSPPP KRRTASPPPP PKRRASPSPP PKRRVSHSPP PKQRSSPVTK RRSPSLSSKH
   661  RKGSSPSRST REARSPQPNK RHSPSPRPRA PQTSSSPPPV RRGASSSPQR RQSPSPSTRP
   721  IRRVSRTPEP KKIKKAASPS PQSVRRVSSS RSVSGSPEPA AKKPPAPPSP VQSQSPSTNW
   781  SPAVPVKKAK SPTPSPSPPR NSDQEGGGKK KKKKKDKKHK KDKKHKKHKK HKKEKAVAAA
   841  AAAAVTPAAI AAATTTLAQE EPVAAPEPKK ETESEAEDNL DDLEKHLREK ALRSMRKAQV
   901  SPQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRRM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

ovary: 81 nTPM
epididymis: 79 nTPM
bone marrow: 71 nTPM
cerebellum: 65 nTPM
cervix: 62 nTPM
fallopian tube: 59 nTPM

Single-cell type

epididymal principal cells: 896 nCPM
epididymal efferent duct absorptive cells: 410 nCPM
early spermatids: 378 nCPM
erythrocyte progenitors: 368 nCPM
basal keratinocytes: 346 nCPM
suprabasal keratinocytes: 310 nCPM

Immune cell

basophil: 33 nTPM
NK-cell: 33 nTPM
non-classical monocyte: 32 nTPM
MAIT T-cell: 29 nTPM
intermediate monocyte: 27 nTPM
neutrophil: 25 nTPM

Brain region

white matter: 89 nTPM
cerebellum: 67 nTPM
choroid plexus: 65 nTPM
basal ganglia: 63 nTPM
pons: 63 nTPM
medulla oblongata: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PWI domain
PWI domain superfamily
PWI domain
Serine/arginine repetitive matrix

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRRM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRRM1 as an antibody target. Whether an autoantibody or antibody against SRRM1 could matter depends on whether native SRRM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRRM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRRM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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