Seroatlas · Human Serome Atlas

CLK3

Dual specificity protein kinase CLK3

Also known as: CLK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49761
Gene: CLK3
Ensembl: ENSG00000179335
Chromosome: 15
Canonical length: 490 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Intermediate filaments

OverviewNCBI Gene

This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>P49761|CLK3
     1  MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR SHDRLPYQRR
    61  YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP YRTRKHAHHC HKRRTRSCSS
   121  ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD WLQERYEIVG NLGEGTFGKV VECLDHARGK
   181  SQVALKIIRN VGKYREAARL EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG
   241  KNTFEFLKEN NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY
   301  NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG WAQPCDVWSI
   361  GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR TRKQKYFYKG GLVWDENSSD
   421  GRYVKENCKP LKSYMLQDSL EHVQLFDLMR RMLEFDPAQR ITLAEALLHP FFAGLTPEER
   481  SFHTSRNPSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 100 nTPM
skeletal muscle: 45 nTPM
testis: 43 nTPM
thymus: 40 nTPM
blood vessel: 40 nTPM
spleen: 40 nTPM

Single-cell type

esophageal apical cells: 172 nCPM
early spermatids: 114 nCPM
cone photoreceptor cells: 91 nCPM
syncytiotrophoblasts: 79 nCPM
epicardial cells: 66 nCPM
extravillous trophoblasts: 64 nCPM

Immune cell

neutrophil: 117 nTPM
non-classical monocyte: 94 nTPM
eosinophil: 89 nTPM
NK-cell: 88 nTPM
T-reg: 85 nTPM
total PBMC: 84 nTPM

Brain region

cerebellum: 44 nTPM
white matter: 39 nTPM
cerebral cortex: 37 nTPM
choroid plexus: 37 nTPM
medulla oblongata: 36 nTPM
thalamus: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.23
gnomAD missense Z: 2.03
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLK3 as an antibody target. Whether an autoantibody or antibody against CLK3 could matter depends on whether native CLK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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