Seroatlas · Human Serome Atlas

MMTAG2

Multiple myeloma tumor-associated protein 2

Also known as: C1orf35, MGC4174, MMTA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BU76
Gene: MMTAG2
Ensembl: ENSG00000143793
Chromosome: 1
Canonical length: 263 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be located in extracellular region; ficolin-1-rich granule lumen; and secretory granule lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q9BU76|MMTAG2
     1  MFGSSRGGVR GGQDQFNWED VKTDKQRENY LGNSLMAPVG RWQKGRDLTW YAKGRAPCAG
    61  PSREEELAAV REAEREALLA ALGYKNVKKQ PTGLSKEDFA EVCKREGGDP EEKGVDRLLG
   121  LGSASGSVGR VAMSREDKEA AKLGLSVFTH HRVESGGPGT SAASARRKPR AEDQTESSCE
   181  SHRKSKKEKK KKKKRKHKKE KKKKDKEHRR PAEATSSPTS PERPRHHHHD SDSNSPCCKR
   241  RKRGHSGDRR SPSRRWHDRG SEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MMTAG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 24 nTPM
skin: 22 nTPM
esophagus: 21 nTPM
ovary: 18 nTPM
cervix: 18 nTPM
vagina: 17 nTPM

Single-cell type

esophageal basal cells: 106 nCPM
gastric progenitor cells: 94 nCPM
migrating cytotrophoblasts: 92 nCPM
cytotrophoblasts: 90 nCPM
esophageal suprabasal cells: 80 nCPM
esophageal apical cells: 79 nCPM

Immune cell

plasmacytoid DC: 49 nTPM
eosinophil: 43 nTPM
myeloid DC: 38 nTPM
memory B-cell: 37 nTPM
naive CD4 T-cell: 36 nTPM
intermediate monocyte: 36 nTPM

Brain region

white matter: 12 nTPM
medulla oblongata: 11 nTPM
pons: 11 nTPM
amygdala: 11 nTPM
cerebral cortex: 11 nTPM
basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Multiple myeloma tumor-associated protein 2-like, N-terminal
Multiple myeloma tumor-associated protein 2-like
Multiple myeloma tumor-associated

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MMTAG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MMTAG2 as an antibody target. Whether an autoantibody or antibody against MMTAG2 could matter depends on whether native MMTAG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MMTAG2 is annotated as secreted, so native MMTAG2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MMTAG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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