Seroatlas · Human Serome Atlas

PRPF38A

Pre-mRNA-splicing factor 38A

Also known as: FLJ14936, PR38A_HUMAN, Prp38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NAV1
Gene: PRPF38A
Ensembl: ENSG00000134748
Chromosome: 1
Canonical length: 312 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NAV1|PRPF38A
     1  MANRTVKDAH SIHGTNPQYL VEKIIRTRIY ESKYWKEECF GLTAELVVDK AMELRFVGGV
    61  YGGNIKPTPF LCLTLKMLQI QPEKDIIVEF IKNEDFKYVR MLGALYMRLT GTAIDCYKYL
   121  EPLYNDYRKI KSQNRNGEFE LMHVDEFIDE LLHSERVCDI ILPRLQKRYV LEEAEQLEPR
   181  VSALEEDMDD VESSEEEEEE DEKLERVPSP DHRRRSYRDL DKPRRSPTLR YRRSRSRSPR
   241  RRSRSPKRRS PSPRRERHRS KSPRRHRSRS RDRRHRSRSK SPGHHRSHRH RSHSKSPERS
   301  KKSHKKSRRG NE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRPF38A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thymus: 20 nTPM
bone marrow: 18 nTPM
retina: 16 nTPM
ovary: 15 nTPM
cerebellum: 15 nTPM
lymph node: 15 nTPM

Single-cell type

esophageal apical cells: 120 nCPM
late primary spermatocytes: 118 nCPM
syncytiotrophoblasts: 111 nCPM
early spermatids: 107 nCPM
neutrophil progenitors: 103 nCPM
extravillous trophoblasts: 94 nCPM

Immune cell

basophil: 12 nTPM
naive CD4 T-cell: 11 nTPM
NK-cell: 11 nTPM
MAIT T-cell: 10 nTPM
memory CD8 T-cell: 9 nTPM
eosinophil: 8.9 nTPM

Brain region

cerebellum: 26 nTPM
white matter: 20 nTPM
midbrain: 19 nTPM
cerebral cortex: 18 nTPM
hypothalamus: 18 nTPM
medulla oblongata: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.77
gnomAD missense Z: 2.11
DepMap mean gene effect: -2.52
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

via spliceosome
mRNA splicing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Pre-mRNA-splicing factor 38
PRP38 family
Pre-mRNA-splicing factor 38, C-terminal
Pre-mRNA-splicing factor 38-associated hydrophilic C-term

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRPF38A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRPF38A as an antibody target. Whether an autoantibody or antibody against PRPF38A could matter depends on whether native PRPF38A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRPF38A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRPF38A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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