Seroatlas · Human Serome Atlas

ARGLU1

Arginine and glutamate-rich protein 1

Also known as: ARGL1_HUMAN, FLJ10154

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWB6
Gene: ARGLU1
Ensembl: ENSG00000134884
Chromosome: 13
Canonical length: 273 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

Enables pre-mRNA binding activity and transcription coactivator activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in cytosol; mitochondrion; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q9NWB6|ARGLU1
     1  MGRSRSRSSS RSKHTKSSKH NKKRSRSRSR SRDKERVRKR SKSRESKRNR RRESRSRSRS
    61  TNTAVSRRER DRERASSPPD RIDIFGRTVS KRSSLDEKQK REEEEKKAEF ERQRKIRQQE
   121  IEEKLIEEET ARRVEELVAK RVEEELEKRK DEIEREVLRR VEEAKRIMEK QLLEELERQR
   181  QAELAAQKAR EEEERAKREE LERILEENNR KIAEAQAKLA EEQLRIVEEQ RKIHEERMKL
   241  EQERQRQQKE EQKIILGKGK SRPKLSFSLK TQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARGLU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 34 nTPM
basal ganglia: 19 nTPM
cerebral cortex: 16 nTPM
hippocampal formation: 16 nTPM
amygdala: 15 nTPM
ovary: 15 nTPM

Single-cell type

tuft cells: 507 nCPM
esophageal apical cells: 465 nCPM
bergmann glia: 462 nCPM
oligodendrocytes: 433 nCPM
vascular endothelial cells: 421 nCPM
leydig cells: 405 nCPM

Immune cell

neutrophil: 46 nTPM
basophil: 45 nTPM
plasmacytoid DC: 34 nTPM
naive B-cell: 33 nTPM
memory B-cell: 30 nTPM
classical monocyte: 24 nTPM

Brain region

cerebellum: 17 nTPM
cerebral cortex: 17 nTPM
white matter: 14 nTPM
amygdala: 13 nTPM
basal ganglia: 13 nTPM
hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.86
gnomAD missense Z: 2.48
DepMap mean gene effect: -0.62
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Arginine and glutamate-rich protein 1
Arginine and glutamate-rich 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARGLU1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARGLU1 as an antibody target. Whether an autoantibody or antibody against ARGLU1 could matter depends on whether native ARGLU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARGLU1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARGLU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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