Seroatlas · Human Serome Atlas

CCNDBP1

Cyclin-D1-binding protein 1

Also known as: CCDB1_HUMAN, DIP1, GCIP, HHM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95273
Gene
CCNDBP1
Ensembl
ENSG00000166946
Chromosome
15
Canonical length
360 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>O95273|CCNDBP1
     1  MASATAPAAA VPTLASPLEQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE MFWRRLNEAA
    61  VTVSREATTL TIVFSQLPLP SPQETQKFCE QVHAAIKAFI AVYYLLPKDQ GITLRKLVRG
   121  ATLDIVDGMA QLMEVLSVTP TQSPENNDLI SYNSVWVACQ QMPQIPRDNK AAALLMLTKN
   181  VDFVKDAHEE MEQAVEECDP YSGLLNDTEE NNSDNHNHED DVLGFPSNQD LYWSEDDQEL
   241  IIPCLALVRA SKACLKKIRM LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC
   301  HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI KELTQSELEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNDBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 19 nTPM
  • cerebellum: 6.6 nTPM
  • adipose tissue: 3.6 nTPM
  • spleen: 3.1 nTPM
  • skin: 2.9 nTPM
  • blood vessel: 2.6 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,449 nCPM
  • esophageal apical cells: 536 nCPM
  • cytotrophoblasts: 415 nCPM
  • migrating cytotrophoblasts: 305 nCPM
  • neutrophils: 270 nCPM
  • platelets: 162 nCPM

Immune cell

  • basophil: 22 nTPM
  • non-classical monocyte: 9.5 nTPM
  • T-reg: 8.4 nTPM
  • neutrophil: 6.2 nTPM
  • naive CD8 T-cell: 5.9 nTPM
  • eosinophil: 5.6 nTPM

Brain region

  • cerebellum: 8.8 nTPM
  • cerebral cortex: 6.1 nTPM
  • hypothalamus: 6.1 nTPM
  • pons: 6.1 nTPM
  • white matter: 5.9 nTPM
  • basal ganglia: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
0.33
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Cyclin-D1-binding protein 1-like
  • Cyclin-D1-binding protein 1-like, N-terminal
  • Cyclin-D1-binding protein 1-like, C-terminal
  • Grap2 and cyclin-D-interacting, N-terminal
  • Grap2 and cyclin-D-interacting, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNDBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNDBP1 as an antibody target. Whether an autoantibody or antibody against CCNDBP1 could matter depends on whether native CCNDBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNDBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNDBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCNDBP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...