Seroatlas · Human Serome Atlas

RPL34

Large ribosomal subunit protein eL34

Also known as: L34, RL34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49207
Gene
RPL34
Ensembl
ENSG00000109475
Chromosome
4
Canonical length
117 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P49207|RPL34
     1  MVQRLTYRRR LSYNTASNKT RLSRTPGNRI VYLYTKKVGK APKSACGVCP GRLRGVRAVR
    61  PKVLMRLSKT KKHVSRAYGG SMCAKCVRDR IKRAFLIEEQ KIVVKVLKAQ AQSQKAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
3,167 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,167 nTPM
  • pancreas: 2,816 nTPM
  • breast: 2,327 nTPM
  • bone marrow: 2,137 nTPM
  • cervix: 2,028 nTPM
  • skin: 1,798 nTPM

Single-cell type

  • decidual stromal cells: 12,410 nCPM
  • ovarian stromal cells: 11,718 nCPM
  • breast secretory cells: 10,816 nCPM
  • suprabasal keratinocytes: 9,928 nCPM
  • extravillous trophoblasts: 9,630 nCPM
  • basal keratinocytes: 9,293 nCPM

Immune cell

  • total PBMC: 12,340 nTPM
  • memory B-cell: 7,820 nTPM
  • naive CD4 T-cell: 7,525 nTPM
  • naive B-cell: 6,495 nTPM
  • naive CD8 T-cell: 5,736 nTPM
  • memory CD4 T-cell: 5,689 nTPM

Brain region

  • spinal cord: 448 nTPM
  • white matter: 429 nTPM
  • thalamus: 406 nTPM
  • basal ganglia: 361 nTPM
  • medulla oblongata: 356 nTPM
  • pons: 345 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.71
gnomAD missense Z
1.4

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein eL34
  • Large ribosomal subunit protein eL34, conserved site
  • Large ribosomal subunit protein eL34, C-terminal domain superfamily
  • Ribosomal protein L34e

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL34 as an antibody target. Whether an autoantibody or antibody against RPL34 could matter depends on whether native RPL34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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