Seroatlas · Human Serome Atlas

NOC3L

Nucleolar complex protein 3 homolog

Also known as: AD24, C10orf117, FAD24, FLJ12820, NOC3L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTT2
Gene: NOC3L
Ensembl: ENSG00000173145
Chromosome: 10
Canonical length: 800 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within fat cell differentiation. Located in mitochondrion; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

800 residues, UniProt reviewed canonical sequence.

>Q8WTT2|NOC3L
     1  MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR QAVKDAVSKK
    61  PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM KDLGQRVSFL TRDLSSSEPV
   121  HAKKRKHERI IDKYEKIPRT LQTAPEKELI HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ
   181  EEERELEEEI IEDPIQELTI EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR
   241  SMLMEQDPDV AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG
   301  LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL VALPHFNFHN
   361  NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG VIKVISGFVK GRNYEVRPEM
   421  LKTFLCLRIK EVEVKKDTED INKPKKFMTF KEKRKSLSRM QRKWKKAEEK LERELREAEA
   481  SESTEKKLKL HTETLNIVFV TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV
   541  LHTLIESGDL SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV
   601  EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR ILMHTFPKTD
   661  LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY HPIVQRFAAH LIAGAPSEGS
   721  GALKPELSRR SATELFEAYS MAEMTFNPPV ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS
   781  SEVATESPLD FTKYLKTSLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOC3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

tonsil: 12 nTPM
lymph node: 12 nTPM
spleen: 11 nTPM
breast: 11 nTPM
thyroid gland: 10 nTPM
testis: 9.7 nTPM

Single-cell type

epicardial cells: 109 nCPM
differentiating spermatogonia: 103 nCPM
early primary spermatocytes: 67 nCPM
erythrocyte progenitors: 60 nCPM
mesothelial cells: 59 nCPM
alveolar cells type 1: 56 nCPM

Immune cell

memory B-cell: 14 nTPM
naive B-cell: 13 nTPM
NK-cell: 8.2 nTPM
naive CD4 T-cell: 5.8 nTPM
MAIT T-cell: 5.5 nTPM
memory CD8 T-cell: 5.5 nTPM

Brain region

white matter: 11 nTPM
medulla oblongata: 11 nTPM
spinal cord: 10 nTPM
basal ganglia: 10 nTPM
pons: 10 nTPM
midbrain: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.69
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

CCAAT-binding factor
Armadillo-type fold
CBF/Mak21 family
Nucleolar complex-associated protein 3, N-terminal
Nucleolar complex-associated protein 3
Nucleolar complex-associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOC3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOC3L as an antibody target. Whether an autoantibody or antibody against NOC3L could matter depends on whether native NOC3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOC3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOC3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...