Seroatlas · Human Serome Atlas

RPL27A

Large ribosomal subunit protein uL15

Also known as: L27A, RL27A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46776
Gene
RPL27A
Ensembl
ENSG00000166441
Chromosome
11
Canonical length
148 aa
Protein class
Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>P46776|RPL27A
     1  MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH
    61  YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ
   121  PVIVKAKFFS RRAEEKIKSV GGACVLVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL27A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
3,221 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,221 nTPM
  • bone marrow: 3,051 nTPM
  • pancreas: 3,026 nTPM
  • skin: 2,704 nTPM
  • esophagus: 2,532 nTPM
  • cervix: 2,439 nTPM

Single-cell type

  • esophageal suprabasal cells: 9,451 nCPM
  • extravillous trophoblasts: 8,618 nCPM
  • decidual stromal cells: 7,386 nCPM
  • esophageal basal cells: 7,317 nCPM
  • migrating cytotrophoblasts: 7,076 nCPM
  • esophageal apical cells: 7,000 nCPM

Immune cell

  • total PBMC: 27,248 nTPM
  • memory B-cell: 13,070 nTPM
  • naive CD4 T-cell: 12,636 nTPM
  • naive B-cell: 11,395 nTPM
  • memory CD4 T-cell: 10,846 nTPM
  • naive CD8 T-cell: 10,724 nTPM

Brain region

  • white matter: 367 nTPM
  • spinal cord: 361 nTPM
  • thalamus: 338 nTPM
  • medulla oblongata: 336 nTPM
  • hypothalamus: 333 nTPM
  • basal ganglia: 324 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.91
gnomAD missense Z
0.93
DepMap mean gene effect
-2.03
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL27A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL27A as an antibody target. Whether an autoantibody or antibody against RPL27A could matter depends on whether native RPL27A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL27A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL27A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL27A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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