MAGEB2
Melanoma-associated antigen B2
Also known as: CT3.2, DAM6, MAGB2_HUMAN, MAGE-XP-2, MGC26438
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15479
- Gene
- MAGEB2
- Ensembl
- ENSG00000099399
- Chromosome
- X
- Canonical length
- 319 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
319 residues, UniProt reviewed canonical sequence.
>O15479|MAGEB2
1 MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA SSSPAAGIPQ
61 EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS TSTKSPSEDP LTRKSGSLVQ
121 FLLYKYKIKK SVTKGEMLKI VGKRFREHFP EILKKASEGL SVVFGLELNK VNPNGHTYTF
181 IDKVDLTDEE SLLSSWDFPR RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV
241 FGEPWKLITK DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP
301 CAFPTHYEEA LKDEEKAGVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MAGEB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- testis: 27 nTPM
- ovary: 0.4 nTPM
- placenta: 0.4 nTPM
- lung: 0.1 nTPM
- tonsil: 0.1 nTPM
- adipose tissue: 0 nTPM
Single-cell type
- undifferentiated spermatogonia: 136 nCPM
- oocytes: 120 nCPM
- differentiating spermatogonia: 54 nCPM
- early primary spermatocytes: 33 nCPM
- late primary spermatocytes: 2.6 nCPM
- late spermatids: 1.8 nCPM
Immune cell
- memory B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MAGEB2.
Disease | ImmuneIEDB
Conditions an epitope on MAGEB2 was assayed in.
- hepatocellular carcinoma T cell
- melanoma T cell
- skin melanoma T cell
- hepatitis B T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -1.3
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of MAGEB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MAGEB2 as an antibody target. Whether an autoantibody or antibody against MAGEB2 could matter depends on whether native MAGEB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MAGEB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MAGEB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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