RPL22

Protein identityUniProt · HPA

UniProt accession

P35268

Gene

RPL22

Ensembl

ENSG00000116251

Chromosome

1

Canonical length

128 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>P35268|RPL22
     1  MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV
    61  VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL RVVANSKESY ELRYFQINQD
   121  EEEEEDED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

1,003 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.04

gnomAD pLI

0.16

gnomAD missense Z

1.67

DepMap mean gene effect

-0.71

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• alpha-beta T cell differentiation
• cytoplasmic translation
• translation
• translation at presynapse

Molecular functions

• heparin binding
• identical protein binding
• RNA binding
• structural constituent of ribosome

Cellular components

• cytoplasm
• cytosol
• cytosolic large ribosomal subunit
• cytosolic ribosome
• extracellular exosome
• focal adhesion
• glutamatergic synapse
• nucleus
• presynapse
• ribonucleoprotein complex

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein eL22
• Large ribosomal subunit protein eL22 superfamily
• Ribosomal L22e protein family

KeywordsUniProt

• Cytoplasm
• Heparin-binding
• Phosphoprotein
• Ribonucleoprotein
• Ribosomal protein
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of RPL22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDC42
• DDX21
• ILF3
• NPM1
• RBM39
• RPL11
• RPL13
• RPL19
• RPL4
• RPL5
• RPS16
• ZCCHC17