Seroatlas · Human Serome Atlas

NSA2

Ribosome biogenesis protein NSA2 homolog

Also known as: FLJ94393, HCLG1, HUSSY-29, NSA2_HUMAN, TINP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95478
Gene: NSA2
Ensembl: ENSG00000164346
Chromosome: 5
Canonical length: 260 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>O95478|NSA2
     1  MPQNEYIELH RKRYGYRLDY HEKKRKKESR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ
    61  MKKTIKMHEK RNTKQKNDEK TPQGAVPAYL LDREGQSRAK VLSNMIKQKR KEKAGKWEVP
   121  LPKVRAQGET EVLKVIRTGK RKKKAWKRMV TKVCFVGDGF TRKPPKYERF IRPMGLRFKK
   181  AHVTHPELKA TFCLPILGVK KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK
   241  YAQVTNNPEN DGCINAVLLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 64 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 64 nTPM
ovary: 58 nTPM
pancreas: 37 nTPM
bone marrow: 37 nTPM
cervix: 36 nTPM
colon: 35 nTPM

Single-cell type

late primary spermatocytes: 612 nCPM
early spermatids: 404 nCPM
fallopian secretory cells: 357 nCPM
decidual stromal cells: 331 nCPM
ovarian stromal cells: 278 nCPM
esophageal basal cells: 278 nCPM

Immune cell

naive CD8 T-cell: 30 nTPM
naive CD4 T-cell: 29 nTPM
memory B-cell: 27 nTPM
T-reg: 27 nTPM
memory CD4 T-cell: 25 nTPM
memory CD8 T-cell: 25 nTPM

Brain region

spinal cord: 20 nTPM
white matter: 20 nTPM
medulla oblongata: 19 nTPM
cerebellum: 19 nTPM
hypothalamus: 18 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.01
gnomAD missense Z: 0.77
DepMap mean gene effect: -1.34
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribosomal protein eS8/ribosomal biogenesis NSA2
Ribosomal protein S8e
Ribosomal biogenesis NSA2 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NSA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSA2 as an antibody target. Whether an autoantibody or antibody against NSA2 could matter depends on whether native NSA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...