COPS9
COP9 signalosome complex subunit 9
Also known as: CSN9_HUMAN, CSNAP, MYEOV2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WXC6
- Gene
- COPS9
- Ensembl
- ENSG00000172428
- Chromosome
- 2
- Canonical length
- 57 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Involved in cellular response to UV; negative regulation of protein neddylation; and positive regulation of cell population proliferation. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
57 residues, UniProt reviewed canonical sequence.
>Q8WXC6|COPS9
1 MKPAVDEMFP EGAGPYVDLD EAGGSTGLLM DLAANEKAVH ADFFNDFEDL FDDDDIQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against COPS9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 521 nTPM
Expression across tissuesHPA
Tissue
- amygdala: 521 nTPM
- basal ganglia: 476 nTPM
- hippocampal formation: 465 nTPM
- cerebral cortex: 442 nTPM
- midbrain: 413 nTPM
- spinal cord: 368 nTPM
Single-cell type
- epididymal principal cells: 846 nCPM
- esophageal suprabasal cells: 755 nCPM
- esophageal apical cells: 707 nCPM
- parietal cells: 645 nCPM
- hofbauer cells: 434 nCPM
- esophageal basal cells: 402 nCPM
Immune cell
- basophil: 517 nTPM
- eosinophil: 417 nTPM
- total PBMC: 416 nTPM
- T-reg: 387 nTPM
- plasmacytoid DC: 366 nTPM
- non-classical monocyte: 332 nTPM
Brain region
- white matter: 153 nTPM
- cerebellum: 138 nTPM
- hippocampal formation: 137 nTPM
- thalamus: 135 nTPM
- spinal cord: 117 nTPM
- midbrain: 117 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.48
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular response to UV
- negative regulation of protein localization to nucleolus
- negative regulation of protein neddylation
- positive regulation of cell population proliferation
Cellular components
Protein domainsUniProt · Pfam · InterPro
- COP9 signalosome complex, subunit 9, metazoa
- Myeloma-overexpressed-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of COPS9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads COPS9 as an antibody target. Whether an autoantibody or antibody against COPS9 could matter depends on whether native COPS9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
COPS9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label COPS9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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