Seroatlas · Human Serome Atlas

HEATR3

HEAT repeat-containing protein 3

Also known as: FLJ20718, HEAT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z4Q2
Gene
HEATR3
Ensembl
ENSG00000155393
Chromosome
16
Canonical length
680 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

680 residues, UniProt reviewed canonical sequence.

>Q7Z4Q2|HEATR3
     1  MGKSRTKRFK RPQFSPTGDC QAEAAAAANG TGGEEDDGPA AELLEKLQHP SAEVRECACA
    61  GLARLVQQRP ALPGLARRDA VRRLGPLLLD PSLAVRETAA GALRNLSACG GFEVCDDMVT
   121  KDIMTPLVAL LKECSAGLDS NEMSLQEKKD QNRNSIENIA NETVNVLWNI CECSSRAVSI
   181  FNKEGCLEIV LKYLSRFPTN VDLAISVAYC LQTVTEDNPE LLKSFSATAL NMLESALLSP
   241  VSSMESLLLK TLVAGTIWNL KDIIPCKSQA EIINALLKIL SEVLGMDAGE MVIQMKEAET
   301  QRLKTAAEAE EILENTNGDD LIEDDEMEGI SHKRRVRRKT FVSDLLPPTD KELRETIALL
   361  TAQQTALEII VNMCCNEDPS DDEWEELSSS DESDAFMENS FSECGGQLFS PLCLSHEVHT
   421  ALTNYLIPKK IFEKTAFPNS IAVDLCSRNP TWKPLIRKMN TIQCRALFCL QSLVSLLDVE
   481  HLGGAAALQT LAQHLSQLLF SQPDFAKHVD FLEAISSALR ALLQTMASKN ISQCMTPDQL
   541  MTLCKAGIHS SNVGVRVNVV SILGITGSVL AKEDGTLETL KNIGCFLLEV TTKDPSLVVA
   601  GEALDALFDV FADGKEAERA SIQIKLLSAL KEFQPVFKMK IRKEGRGNYS TDQLCVLDNV
   661  KMNLRRFIAY QETVEKRLTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEATR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
5.3 nTPM

Expression across tissuesHPA

Tissue

  • appendix: 5.3 nTPM
  • skeletal muscle: 4.9 nTPM
  • lymph node: 4.3 nTPM
  • tongue: 4.1 nTPM
  • tonsil: 4.1 nTPM
  • rectum: 3.9 nTPM

Single-cell type

  • monocytes: 64 nCPM
  • macrophages: 57 nCPM
  • kupffer cells: 50 nCPM
  • myonuclei: 43 nCPM
  • cone photoreceptor cells: 41 nCPM
  • brain inhibitory neurons: 39 nCPM

Immune cell

  • non-classical monocyte: 0.9 nTPM
  • intermediate monocyte: 0.5 nTPM
  • myeloid DC: 0.4 nTPM
  • classical monocyte: 0.3 nTPM
  • plasmacytoid DC: 0.3 nTPM
  • gdT-cell: 0.2 nTPM

Brain region

  • choroid plexus: 1.8 nTPM
  • cerebellum: 1.7 nTPM
  • basal ganglia: 1.3 nTPM
  • cerebral cortex: 1.3 nTPM
  • hypothalamus: 1.3 nTPM
  • amygdala: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HEATR3.

Disease | AllUniProt

Conditions HEATR3 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 113 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
1.14
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HEATR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEATR3 as an antibody target. Whether an autoantibody or antibody against HEATR3 could matter depends on whether native HEATR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEATR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEATR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HEATR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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