Seroatlas · Human Serome Atlas

LYAR

Cell growth-regulating nucleolar protein

Also known as: LYAR_HUMAN, ZC2HC2, ZLYAR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NX58
Gene
LYAR
Ensembl
ENSG00000145220
Chromosome
4
Canonical length
379 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Enables several functions, including DNA-binding transcription factor binding activity; identical protein binding activity; and transcription regulator inhibitor activity. Involved in several processes, including erythrocyte development; negative regulation of innate immune response; and regulation of DNA-templated transcription. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>Q9NX58|LYAR
     1  MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK CISEDQKYGG
    61  KGYEGKTHKG DIKQQAWIQK ISELIKRPNV SPKVRELLEQ ISAFDNVPRK KAKFQNWMKN
   121  SLKVHNESIL DQVWNIFSEA SNSEPVNKEQ DQRPLHPVAN PHAEISTKVP ASKVKDAVEQ
   181  QGEVKKNKRE RKEERQKKRK REKKELKLEN HQENSRNQKP KKRKKGQEAD LEAGGEEVPE
   241  ANGSAGKRSK KKKQRKDSAS EEEARVGAGK RKRRHSEVET DSKKKKMKLP EHPEGGEPED
   301  DEAPAKGKFN WKGTIKAILK QAPDNEITIK KLRKKVLAQY YTVTDEHHRS EEELLVIFNK
   361  KISKNPTFKL LKDKVKLVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYAR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • testis: 95 nTPM
  • lymph node: 23 nTPM
  • skeletal muscle: 20 nTPM
  • bone marrow: 19 nTPM
  • appendix: 19 nTPM
  • spleen: 18 nTPM

Single-cell type

  • late primary spermatocytes: 1,610 nCPM
  • early primary spermatocytes: 189 nCPM
  • nk-cells: 145 nCPM
  • t-cells: 135 nCPM
  • esophageal basal cells: 129 nCPM
  • late spermatids: 128 nCPM

Immune cell

  • MAIT T-cell: 86 nTPM
  • memory CD8 T-cell: 80 nTPM
  • gdT-cell: 74 nTPM
  • memory CD4 T-cell: 48 nTPM
  • naive CD8 T-cell: 48 nTPM
  • non-classical monocyte: 39 nTPM

Brain region

  • white matter: 7.9 nTPM
  • hypothalamus: 7.6 nTPM
  • medulla oblongata: 7.5 nTPM
  • cerebral cortex: 7 nTPM
  • pons: 6.9 nTPM
  • midbrain: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
-0.22
DepMap mean gene effect
0.2
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Zinc finger C2H2 superfamily
  • Zinc finger, C2H2, LYAR-type
  • Cell growth-regulating nucleolar protein
  • Acetyl-coA carboxylase zinc finger domain
  • Cell growth-regulating nucleolar protein-like, winged helix domain
  • LYAR-type C2HC zinc finger
  • Acetyl-CoA carboxylase zinc finger domain
  • LYAR family winged helix domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LYAR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYAR as an antibody target. Whether an autoantibody or antibody against LYAR could matter depends on whether native LYAR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYAR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYAR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LYAR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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