Seroatlas · Human Serome Atlas

SERPINB2

Plasminogen activator inhibitor 2

Also known as: HsT1201, PAI-2, PAI2, PAI2_HUMAN, PLANH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P05120
Gene: SERPINB2
Ensembl: ENSG00000197632
Chromosome: 18
Canonical length: 415 aa
Protein class: Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in fibrinolysis and negative regulation of apoptotic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in cornified envelope and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>P05120|SERPINB2
     1  MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF
    61  NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA DKIHSSFRSL SSAINASTGN
   121  YLLESVNKLF GEKSASFREE YIRLCQKYYS SEPQAVDFLE CAEEARKKIN SWVKTQTKGK
   181  IPNLLPEGSV DGDTRMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK
   241  LNIGYIEDLK AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM
   301  AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF LSEVFHQAMV
   361  DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH KITNCILFFG RFSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 225 nTPM

Expression across tissuesHPA

Tissue

esophagus: 225 nTPM
skin: 84 nTPM
tonsil: 76 nTPM
placenta: 47 nTPM
vagina: 43 nTPM
bone marrow: 34 nTPM

Single-cell type

epicardial cells: 293 nCPM
monocytes: 219 nCPM
ocular epithelial cells: 207 nCPM
esophageal apical cells: 156 nCPM
basal keratinocytes: 95 nCPM
suprabasal keratinocytes: 75 nCPM

Immune cell

basophil: 22 nTPM
eosinophil: 10 nTPM
classical monocyte: 4.9 nTPM
total PBMC: 1.3 nTPM
myeloid DC: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

cerebral cortex: 2.9 nTPM
thalamus: 2.5 nTPM
hypothalamus: 0.9 nTPM
midbrain: 0.2 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.77
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERPINB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PSMB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINB2 as an antibody target. Whether an autoantibody or antibody against SERPINB2 could matter depends on whether native SERPINB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINB2 is annotated as secreted, so native SERPINB2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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