Seroatlas · Human Serome Atlas

PSME3IP1

PSME3-interacting protein

Also known as: C16orf94, FAM192A, NIP30, PIP30, PIP30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZU8
Gene: PSME3IP1
Ensembl: ENSG00000172775
Chromosome: 16
Canonical length: 254 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Involved in negative regulation of proteasomal protein catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q9GZU8|PSME3IP1
     1  MDGGDDGNLI IKKRFVSEAE LDERRKRRQE EWEKVRKPED PEECPEEVYD PRSLYERLQE
    61  QKDRKQQEYE EQFKFKNMVR GLDEDETNFL DEVSRQQELI EKQRREEELK ELKEYRNNLK
   121  KVGISQENKK EVEKKLTVKP IETKNKFSQA KLLAGAVKHK SSESGNSVKR LKPDPEPDDK
   181  NQEPSSCKSL GNTSLSGPSI HCPSAAVCIG ILPGLGAYSG SSDSESSSDS EGTINATGKI
   241  VSSIFRTNTF LEAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSME3IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 143 nTPM
midbrain: 91 nTPM
testis: 90 nTPM
tonsil: 90 nTPM
spleen: 89 nTPM
spinal cord: 89 nTPM

Single-cell type

late spermatids: 344 nCPM
early spermatids: 241 nCPM
late primary spermatocytes: 198 nCPM
neutrophils: 163 nCPM
esophageal apical cells: 124 nCPM
neutrophil progenitors: 118 nCPM

Immune cell

basophil: 171 nTPM
eosinophil: 125 nTPM
non-classical monocyte: 124 nTPM
neutrophil: 108 nTPM
intermediate monocyte: 93 nTPM
myeloid DC: 90 nTPM

Brain region

white matter: 159 nTPM
basal ganglia: 141 nTPM
medulla oblongata: 139 nTPM
spinal cord: 132 nTPM
hypothalamus: 132 nTPM
midbrain: 131 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.19
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

FAM192A/Fyv6, N-terminal
PSME3-interacting protein
FAM192A/Fyv6, N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSME3IP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSME3IP1 as an antibody target. Whether an autoantibody or antibody against PSME3IP1 could matter depends on whether native PSME3IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSME3IP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSME3IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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