Seroatlas · Human Serome Atlas

MAVS

Mitochondrial antiviral-signaling protein

Also known as: Cardif, IPS-1, KIAA1271, MAVS_HUMAN, VISA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z434
Gene
MAVS
Ensembl
ENSG00000088888
Chromosome
20
Canonical length
540 aa
Protein class
Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q7Z434|MAVS
     1  MPFAEDKTYK YICRNFSNFC NVDVVEILPY LPCLTARDQD RLRATCTLSG NRDTLWHLFN
    61  TLQRRPGWVE YFIAALRGCE LVDLADEVAS VYQSYQPRTS DRPPDPLEPP SLPAERPGPP
   121  TPAAAHSIPY NSCREKEPSY PMPVQETQAP ESPGENSEQA LQTLSPRAIP RNPDGGPLES
   181  SSDLAALSPL TSSGHQEQDT ELGSTHTAGA TSSLTPSRGP VSPSVSFQPL ARSTPRASRL
   241  PGPTGSVVST GTSFSSSSPG LASAGAAEGK QGAESDQAEP IICSSGAEAP ANSLPSKVPT
   301  TLMPVNTVAL KVPANPASVS TVPSKLPTSS KPPGAVPSNA LTNPAPSKLP INSTRAGMVP
   361  SKVPTSMVLT KVSASTVPTD GSSRNEETPA APTPAGATGG SSAWLDSSSE NRGLGSELSK
   421  PGVLASQVDS PFSGCFEDLA ISASTSLGMG PCHGPEENEY KSEGTFGIHV AENPSIQLLE
   481  GNPGPPADPD GGPRPQADRK FQEREVPCHR PSPGALWLQV AVTGVLVVTL LVVLYRRRLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAVS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 35 nTPM
  • tongue: 27 nTPM
  • heart muscle: 20 nTPM
  • colon: 18 nTPM
  • skin: 18 nTPM
  • pancreas: 17 nTPM

Single-cell type

  • platelets: 182 nCPM
  • myonuclei: 125 nCPM
  • neutrophil progenitors: 119 nCPM
  • colonocytes: 99 nCPM
  • erythrocyte progenitors: 96 nCPM
  • thymic myoid cells: 78 nCPM

Immune cell

  • classical monocyte: 2.1 nTPM
  • eosinophil: 2 nTPM
  • non-classical monocyte: 1.9 nTPM
  • neutrophil: 1.8 nTPM
  • NK-cell: 1.8 nTPM
  • basophil: 1.7 nTPM

Brain region

  • medulla oblongata: 43 nTPM
  • white matter: 37 nTPM
  • thalamus: 37 nTPM
  • basal ganglia: 37 nTPM
  • midbrain: 36 nTPM
  • pons: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.3
gnomAD pLI
0
gnomAD missense Z
0.52
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAVS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAVS as an antibody target. Whether an autoantibody or antibody against MAVS could matter depends on whether native MAVS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAVS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAVS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAVS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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