ABL2

Protein identityUniProt · HPA

UniProt accession

P42684

Gene

ABL2

Ensembl

ENSG00000143322

Chromosome

1

Canonical length

1182 aa

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Intermediate filaments,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

1182 residues, UniProt reviewed canonical sequence.

>P42684|ABL2
     1  MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE
    61  DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA
   121  SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR
   181  SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST
   241  LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG
   301  EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV
   361  TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN
   421  HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT
   481  YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE
   541  TMFHDSSISE EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE
   601  NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR
   661  NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG FSFTPAQQEA NLVPPKCYGG
   721  SFAQRNLCND DGGGGGGSGT AGGGWSGITG FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR
   781  SNSTSSMSSG LPEQDRMAMT LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES
   841  AAPSRERPKA KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG
   901  MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG TDSQGNKFKL
   961  LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS DPTEEPTALT AGQSTSETQE
  1021  GGKKAALGAV PISGKAGRPV MPPPQVPLPT SSISPAKMAN GTAGTKVALR KTKQAAEKIS
  1081  ADKISKEALL ECADLLSSAL TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV
  1141  SKLELSLQEL QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

11 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ABL2.

Disease | ImmuneIEDB

Conditions an epitope on ABL2 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell
• sleep disorder B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.58

gnomAD pLI

0

gnomAD missense Z

1.69

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cellular response to oxidative stress
• cellular response to retinoic acid
• epidermal growth factor receptor signaling pathway
• exploration behavior
• negative regulation of Rho protein signal transduction
• peptidyl-tyrosine phosphorylation
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of cytosolic calcium ion concentration
• positive regulation of establishment of T cell polarity
• positive regulation of neuron projection development
• positive regulation of T cell migration
• protein modification process
• regulation of actin cytoskeleton organization
• regulation of autophagy
• regulation of cell adhesion
• regulation of cell motility
• regulation of endocytosis
• signal transduction

Molecular functions

• actin filament binding
• actin monomer binding
• ATP binding
• enzyme activator activity
• enzyme binding
• magnesium ion binding
• manganese ion binding
• non-membrane spanning protein tyrosine kinase activity
• phosphotyrosine residue binding
• protein kinase activity
• protein tyrosine kinase activity

Cellular components

• actin cytoskeleton
• cytosol
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• SH2 domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• SH3 domain
• Tyrosine-protein kinase, active site
• Protein kinase-like domain superfamily
• F-actin binding
• Protein kinase, ATP binding site
• Tyrosine-protein kinase, catalytic domain
• Tyrosine-protein kinase ABL, SH2 domain
• SH3-like domain superfamily
• SH2 domain superfamily
• Non-receptor tyrosine kinases involved in cell signaling
• SH2 domain
• SH3 domain
• Protein tyrosine and serine/threonine kinase
• F-actin binding

KeywordsUniProt

• Acetylation
• ATP-binding
• Cell adhesion
• Cytoplasm
• Cytoskeleton
• Kinase
• Lipoprotein
• Magnesium
• Manganese
• Metal-binding
• Myristate
• Nucleotide-binding
• Phosphoprotein
• SH2 domain
• SH3 domain
• Transferase
• Tyrosine-protein kinase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of ABL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CTTN
• PSMA7
• RIN1
• CRK
• EGFR
• NCK1
• NCKAP1