Seroatlas · Human Serome Atlas

AIMP1

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Also known as: AIMP1_HUMAN, EMAP-2, EMAPII, p43, SCYE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12904
Gene
AIMP1
Ensembl
ENSG00000164022
Chromosome
4
Canonical length
312 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Cytosol
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q12904|AIMP1
     1  MANNDAVLKR LEQKGAEADQ IIEYLKQQVS LLKEKAILQA TLREEKKLRV ENAKLKKEIE
    61  ELKQELIQAE IQNGVKQIPF PSGTPLHANS MVSENVIQST AVTTVSSGTK EQIKGGTGDE
   121  KKAKEKIEKK GEKKEKKQQS IAGSADSKPI DVSRLDLRIG CIITARKHPD ADSLYVEEVD
   181  VGEIAPRTVV SGLVNHVPLE QMQNRMVILL CNLKPAKMRG VLSQAMVMCA SSPEKIEILA
   241  PPNGSVPGDR ITFDAFPGEP DKELNPKKKI WEQIQPDLHT NDECVATYKG VPFEVKGKGV
   301  CRAQTMSNSG IK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIMP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 73 nTPM
  • bone marrow: 70 nTPM
  • tongue: 60 nTPM
  • rectum: 52 nTPM
  • breast: 52 nTPM
  • thyroid gland: 49 nTPM

Single-cell type

  • esophageal suprabasal cells: 244 nCPM
  • esophageal apical cells: 209 nCPM
  • cardiomyocytes: 204 nCPM
  • esophageal basal cells: 204 nCPM
  • extravillous trophoblasts: 197 nCPM
  • endometrial glandular cells: 193 nCPM

Immune cell

  • T-reg: 84 nTPM
  • non-classical monocyte: 83 nTPM
  • plasmacytoid DC: 81 nTPM
  • intermediate monocyte: 71 nTPM
  • basophil: 68 nTPM
  • myeloid DC: 67 nTPM

Brain region

  • white matter: 34 nTPM
  • cerebellum: 33 nTPM
  • medulla oblongata: 31 nTPM
  • basal ganglia: 30 nTPM
  • cerebral cortex: 30 nTPM
  • midbrain: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AIMP1.

Disease | AllUniProt

Conditions AIMP1 is implicated in, by any mechanism.

  • Leukodystrophy, hypomyelinating, 3 (HLD3) MIM:260600

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 166 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypomyelinating leukodystrophy 3
  • AIMP1-related disorder
  • Hypotonia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIMP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIMP1 as an antibody target. Whether an autoantibody or antibody against AIMP1 could matter depends on whether native AIMP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIMP1 is annotated as secreted, so native AIMP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AIMP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AIMP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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